Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The MT-RNR2 1811A > G variant likely does not play a major role in schizophrenia, as it was not associated with clinical, psychopathological, or neuropsychological variables, and the MT-ATP6 9110T > C p.Ile195Thr variant did not result in differences in the oxidative and enzymatic functions of the mitochondrial respiratory chain.
|
25132006 |
2014 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has previously been shown that CLSP is recruited via the bloodstream into the central nervous system where it likely exerts a neuroprotective effect against toxicity related to Alzheimer's disease (AD) by binding to the heterotrimeric humanin receptor and activating intracellular survival signaling.
|
31038250 |
2019 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer's Disease through the suppression of inflammatory IL-6 cytokine receptors.
|
30381074 |
2019 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism by which S14G-humanin (HNG) improved autophagy and insulin signaling in AD brain.
|
29058763 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD).
|
29265109 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin and calmodulin-like skin protein (CLSP) inhibits Alzheimer disease (AD)-related neuronal cell death via the heterotrimeric humanin receptor in vitro.
|
29164613 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the peptidic nature of HN presents challenges in its development as a therapeutic for AD.
|
29161500 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many cells/tissues.
|
28458518 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults.
|
28361841 |
2017 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Calmodulin-like skin protein (CLSP) is a secreted peptide that inhibits neuronal cell death, linked to Alzheimer's disease (AD), by binding to the heterotrimeric humanin receptor and activating an intracellular survival pathway.
|
28592211 |
2017 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease.
|
27814910 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that HN can suppress neuroinflammation and the associated cognitive deficit in a wider range of neurological disorders beyond Alzheimer's disease.
|
29070438 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer's disease.
|
26062019 |
2015 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.
|
24969584 |
2015 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin can alter the mechanisms involved in AD and T2DM pathogenesis.
|
24365186 |
2014 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin-mediated inhibition of neuronal cell death, caused by an Alzheimer's disease (AD)-linked mutant gene occurs via binding of Humanin to its heterotrimeric Humanin receptor (htHNR), which results in the activation of the Janus-associated kinases (JAKs) and signal transducer and activator and transcription 3 (STAT3) signaling pathway.
|
25138702 |
2014 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The neuroprotective effect of Humanin against Alzheimer disease (AD)-related death is mediated by the binding of Humanin to its heterotrimeric Humanin receptor composed of ciliary neurotrophic receptor α, WSX-1, and gp130, as well as the activation of intracellular signaling pathways including a JAK2 and STAT3 signaling axis.
|
23861391 |
2013 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
To mediate the protective effect in AD-related death models, Humanin signals via a cell-surface receptor that is generally composed of three subunits: ciliary neurotrophic factor receptor α, WSX-1 and gp130 (heterotrimeric Humanin receptor; htHNR).
|
23519124 |
2013 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These included targeted delivery of anti-apoptotic protein humanin through the blood-brain barrier (BBB) to neuronal cells, specific inhibition of caspase-3 activation to inhibit the early triggering of AD progression, and delivery of humanin into the cytoplasm of neuronal cells undergoing apoptosis where it exerts its anti-apoptotic functions effectively.
|
23298615 |
2013 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Humanin (HN), a 24-amino acid peptide encoded by the mitochondrial 16S rRNA gene, was discovered by screening a cDNA library from the occipital cortex of a patient with Alzheimer's disease (AD) for a protection factor against AD-relevant insults.
|
23532874 |
2013 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-apoptotic function against neuronal cell death caused by Alzheimer's disease.
|
20562421 |
2010 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The structural and dynamical properties of Humanin, a small peptide with neuroprotective activity against the insults of the Alzheimer's disease-related genes and the neurotoxic amyloid peptide, are studied in two different environments by molecular dynamics simulation.
|
18597547 |
2008 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
While a broad range of activities of HN against AD-related insults is discovered, the detailed mechanism of its action is still obscure.
|
18781936 |
2008 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease.
|
16639504 |
2006 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Humanin (HN) was originally identified as an endogenous peptide that protects neuronal cells from apoptosis by mutant Alzheimer's disease genes.
|
15752543 |
2005 |