|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Morphological changes, mRNA, and protein expression levels for the inflammatory marker cyclooxygenase-2; the lineage-determining transcription factors TAp63 (squamous), CDX2, and SOX9 (both columnar); and the columnar lineage markers Villin, Muc-2, CK8, and mAb Das-1 (incomplete phenotype of intestinal metaplasia) were assessed every 10 wk.
|
28336546 |
2017 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Some nuclear expressions of MUC2 and MUC6 were noted in children without intestinal metaplasia.
|
25704078 |
2015 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
All of the tumors with intestinal metaplasia were MUC2-positive.
|
21331986 |
2010 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Biopsies were immunohistochemically stained for apoptosis by single-stranded DNA, for proliferation by Ki-67 antibodies and for intestinal metaplasia MUC2, MUC5AC, MUC6 and CD10.
|
15046186 |
2004 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
MUC2 was expressed in both dysplastic and intestinal metaplasia areas.
|
15220684 |
2004 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis.
|
15048136 |
2004 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, this work demonstrates that Cdx-2 activates the expression of MUC2 mucin gene in gastric cells, inducing an intestinal transdifferentiation phenotype that parallels what is observed both in intestinal metaplasia and some gastric carcinomas.
|
14525978 |
2003 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The expression of CDX2 precedes those of CDX1, sucrase-isomaltase, other intestine-specific genes (human defensin-5, alkaline phosphatase), and MUC2 during the progression of intestinal metaplasia.
|
11871772 |
2002 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In gastric tumors, and in early preneoplastic lesions such as intestinal metaplasia, the glycosylation pattern detected in normal stomach is lost and, intestinal mucins, MUC2 and MUC4, can be ectopically detected in the gastric epithelium.
|
11578953 |
2001 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of MUC2 and MUC4 in black stone-containing gallbladder epithelium indicated that intestinal metaplasia and altered mucin genes could occur in diseased gallbladders.
|
11831115 |
2001 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Barrett's metaplasia was also associated with a specific MUC gene expression pattern, since the gastric apomucin mRNAs, MUC5AC and MUC6, were expressed in gastric metaplasia, and the intestinal apomucin mRNAs, MUC3, MUC4 and mostly MUC2, in intestinal metaplasia.
|
11093805 |
2000 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Intestinal metaplasia is characterized by an intestinal-type pattern with MUC2 and MUC3 mRNA expression.
|
11101634 |
2000 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data indicate that MUC2 mucin is expressed in gastric regenerative epithelium in addition to intestinal metaplasia and intestinal type adenocarcinoma.
|
10633292 |
1999 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The intestinal mucin MUC2 was expressed in every case of incomplete intestinal metaplasia, mostly in goblet cells.
|
10070955 |
1999 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In contrast, high levels of MUC2 and MUC3 mucin mRNA and immunoreactive protein were found in specimens with intestinal metaplasia.
|
7780985 |
1995 |