|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that MYC/MYCL overexpression in SCLC cells overrides the need of HIF-1 activity in response to hypoxia by inducing glutaminolysis and lipogenesis.
|
28430666 |
2017 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
While MYC shares major features with its paralogs MYCN and MYCL, the sensitivity to Aurora kinase inhibitors is unique for MYC-driven SCLC.
|
28737478 |
2017 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Silencing of MYCL1 in SCLC cell lines that had the RLF-MYCL1 fusion decreased cell proliferation.
|
22941189 |
2012 |
|
Small cell carcinoma of lung
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Silencing of MYCL1 in SCLC cell lines that had the RLF-MYCL1 fusion decreased cell proliferation.
|
22941189 |
2012 |
|
Small cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings define a 3'-UTR SNP in the human L-MYC oncogene that may increase susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.
|
21676885 |
2011 |
|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
L-Myc is related to the c-Myc proto-oncogene, has transforming activity, and is amplified in the closely related small cell lung cancer.
|
19020549 |
2009 |
|
Small cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified localized DNA amplifications corresponding to oncogenes known to be amplified in SCLC, including MYC (8q24), MYCN (2p24) and MYCL1 (1p34).
|
16116477 |
2006 |
|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Candidate genes for these amplifications include the l-MYC (1p32) and n-MYC (2p24.1) oncogenes, which have been previously found to be overexpressed in SCLC.
|
11494021 |
2001 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mechanism of all-trans-retinoic acid-mediated L-myc gene regulation in small cell lung cancer.
|
8934535 |
1996 |
|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Together with unique characteristics of the L-myc gene, including: (a) a frequently amplified and overexpressed state in SCLC; and (b) very restricted and low-level expression in human adult tissues, the present data indicate that L-myc is a good candidate for the target gene for antisense DNA therapy based on molecular biological diagnosis in SCLC.
|
7882365 |
1995 |
|
Small cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, we also demonstrated how rearrangements affecting the L-myc gene at this locus in small-cell lung cancer can be visualized with fiber-FISH.
|
8595900 |
1995 |
|
Small cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of interest, 5 SCLC lines with high levels of myc gene family expression related to c-, N-, or L-myc gene amplification exhibited growth inhibition (28-87%), whereas 2 non-SCLC lines actually showed growth stimulation after treatment with 1 microM RA.
|
8274449 |
1993 |
|
Small cell carcinoma of lung
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Complex intrachromosomal rearrangement in the process of amplification of the L-myc gene in small-cell lung cancer.
|
1312669 |
1992 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here two independent small cell lung carcinoma (SCLC) cell lines were found to express similar novel proteins antigenically related to L-myc. cDNAs corresponding to these proteins were cloned and shown to encode chimeric polypeptides with amino-terminal sequences from a novel gene named rlf joined to the L-myc protein.
|
1851085 |
1991 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have recently found the L-myc gene involved in a gene fusion in small-cell lung cancer (SCLC).
|
1649386 |
1991 |
|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Amplification and elevated expression of the L-myc gene has been detected in a subset of small cell lung carcinoma (SCLC) cell lines.
|
2548855 |
1989 |
|
Small cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We analyzed in detail the structure of the L-myc gene isolated from human placental DNA and characterized its expression in several small-cell lung cancer cell lines.
|
2827002 |
1988 |
|
Small cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Organization of the L-myc gene was determined by comparing its sequence to those of the L-myc psi gene and an L-myc cDNA clone derived from a human small cell lung carcinoma.
|
3322939 |
1987 |