Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors.
|
6505694 |
1984 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have analyzed a 3.8 kb Eco RI fragment of genomic DNA obtained from the amplified N-myc gene of human neuroblastoma cell line BE(2)-C. This fragment contains an exon with an open reading frame encoding approximately 170 amino acids of the carboxy-terminal end of the putative N-myc protein.
|
2987858 |
1985 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The N-myc gene, first detected by its homology to the second exon of the c-myc gene, is amplified and/or expressed in tumours or cell lines derived from neuroblastoma, retinoblastoma and SCLC.
|
2997622 |
1985 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have demonstrated that the entire murine N-myc gene and the sequences necessary for its expression in human neuroblastoma cells are contained within a 7.4-kilobase murine genomic clone.
|
3513190 |
1986 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Identification and characterization of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities.
|
2426708 |
1986 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Amplification and expression of the N-myc gene in neuroblastoma.
|
3569354 |
1987 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, extra-copies of cellular oncogenes have been located in tumor cells in vivo; particularly N-myc gene amplification was discovered in advanced stage of neuroblastoma (NB).
|
3314672 |
1987 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These are frequently seen in neuroblastoma and have been shown to be the site of amplification of the NMYC oncogene.
|
2439257 |
1987 |
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene amplification and rearrangements are discussed through review of recent work on the N-myc gene in neuroblastoma and the epidermal growth factor receptor (EGFR) gene in glioblastoma.
|
3059215 |
1988 |
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the N-myc gene has been reported in a number of tumour types including neuroblastoma, retinoblastoma and small cell lung carcinoma.
|
2834684 |
1988 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The precise role of the N-myc gene in the pathogenesis of neuroblastoma remains unclear.
|
2461451 |
1988 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is concluded that in situ hybridization of tissue sections is as effective as Southern blot analysis of tumor cell DNA in identifying human neuroblastoma tumors in which the N-myc gene is of prognostic significance.
|
2454580 |
1988 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to this criterion, 14 cases (12 cases of neuroblastoma and 2 cases of ganglioneuroblastoma) were positive for N-myc gene amplification of 27 cases (18 cases of neuroblastoma, 5 cases of ganglioneuroblastoma, and 4 cases of composite ganglioneuroblastoma).
|
3222254 |
1988 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies indicate a regulatory interaction between MYC and NMYC in neuroblastoma cells.
|
2810395 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the human neuroblastoma cell line IMR32 the N-myc gene happens to be amplified and actively expressed, whereas no stable c-myc RNA can be detected in the same cells.
|
2669755 |
1989 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of N-myc gene product was reduced in neuroblastoma cell line SK-N-DZ differentiated by retinoic acid as compared with untreated cells.
|
2480694 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, flow cytometric analysis of DNA content together with N-myc gene dosage allowed us to distinguish two different subsets of neuroblastoma tumors: the first one aneuploid, with single-copy N-myc, usually observed in patients younger than 24 months with localized or IV-S clinical stages; the second one near-diploid, with frequent N-myc amplification, usually observed in patients older than 24 months with advanced clinical stages.
|
2920475 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-myc gene amplification of the gynecological malignant tumor cell lines and a neuroblastoma cell line was studied by the Southern hybridization method along with the production of neuron-specific enolase (NSE) by these cell lines.
|
2542141 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine directly whether NMYC might modulate class I MHC expression in NB, we transfected a plasmid containing a recombinant NMYC gene into two tumor cell lines derived from a NB and a related neuroepithelioma tumor.
|
2687378 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is concluded that immunohistochemical staining for the N-myc gene product will facilitate prediction of the prognosis of patients with neuroblastoma.
|
2921345 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of DNA rearrangements of N-myc gene amplification in three neuroblastoma cell lines by pulsed-field gel electrophoresis.
|
2753147 |
1989 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
With the identification of amplified MYCN and the demonstration of a consensus deletion spanning the chromosome 1p36.1-2 region it appears now likely that both amplification of a cellular oncogene and loss of a tumour-suppressor gene play an important role in neuroblastoma.
|
1669692 |
1990 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-myc gene amplification and other prognosis-associated factors in neuroblastoma.
|
2262866 |
1990 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because N-myc protein is thought to have a regulatory role, prolongation of the half-life of this protein may be an important factor in the regulation of growth in NBs which lack N-myc amplification and rapidly progress.
|
2284101 |
1990 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the interrelationships between these two parameters, tumor samples from 18 patients with neuroblastoma were analyzed for both total DNA and N-myc gene content.
|
2306684 |
1990 |