Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the non-muscle myosin IIA gene (MYH9) are associated with focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease (ESRD) in African Americans and FSGS in European Americans.
|
21968013 |
2012 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considerable attention has been focused on how the APOL1/MYH9 locus determines susceptibility to focal segmental glomerulosclerosis, including HIV-associated nephropathy (HIVAN).
|
22791322 |
2012 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mapping by admixture linkage disequilibrium (MALD; or admixture mapping) recently led to a major breakthrough in hypertension-attributed kidney disease in African Americans, demonstrating the role of the apolipoprotein L1 (APOL1) and nonmuscle myosin heavy chain 9 (MYH9) genes in this primary kidney disease residing in the spectrum of focal segmental glomerulosclerosis.
|
22614628 |
2012 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this replication study, we examined the six top-most associated variants in APOL1 and MYH9 in an independent cohort of African Americans with various nephropathies (44 with FSGS, 21 with HIVAN, 32 with IgA nephropathy, and 74 healthy controls).
|
21997397 |
2011 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The myosin, heavy chain 9, non-muscle (MYH9) and apolipoprotein L1 (APOL1) genes have been associated with risk for focal segmental glomerulosclerosis and end-stage renal disease in African Americans.
|
21910715 |
2011 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
MYH9-associated nephropathies reside in the spectrum of focal segmental glomerulosclerosis/focal global glomerulosclerosis.
|
21074826 |
2011 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies linked single-nucleotide polymorphisms (SNPs) at the MYH9 locus to chronic kidney disease among African-Americans, particularly glomerular diseases such as HIV nephropathy and idiopathic focal and segmental glomerulosclerosis (FSGS).
|
21402784 |
2011 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While no association was observed in the cohort of European Americans, the case-control comparison of African Americans found variants within a 60 kb region of chromosome 22 containing part of the APOL1 and MYH9 genes associated with increased risk of FSGS.
|
20668430 |
2010 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To narrow the region of association and identify potential causal variation, we performed a dense-mapping study using 79 MYH9 SNPs in AA populations with FSGS, HIVAN and H-ESKD (typed for a subset of 46 SNPs), for a total of 2496 cases and controls.
|
20124285 |
2010 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
MYH9 will re-categorize focal segmental glomerulosclerosis and related disorders, and has clarified the relationship between hypertension and kidney disease.
|
19838113 |
2010 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The nonmuscle myosin heavy chain 9 gene (MYH9) is associated with a spectrum of kidney diseases in African Americans, including idiopathic focal global glomerulosclerosis historically attributed to hypertension, idiopathic focal segmental glomerulosclerosis, and the collapsing variant of focal segmental glomerulosclerosis [HIV-associated nephropathy (HIVAN)].
|
20051853 |
2010 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent linkage analyses of nondiabetic African-American patients with focal segmental glomerulosclerosis (FSGS) have identified MYH9, encoding nonmuscle myosin heavy chain IIA (NMMHC-IIA), as a gene having a critical role in this disease.
|
20200500 |
2010 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MYH9 variation has a smaller but still highly significant effect on nondiabetic kidney disease, and a weaker but significant effect on diabetic kidney disease; it is unclear whether underlying cryptic FSGS is responsible for the MYH9 association with these diseases.
|
20347641 |
2010 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
New evidence suggests that MYH9 gene alterations also are associated with a greater risk of focal segmental glomerulosclerosis and hypertensive nephrosclerosis in African Americans.
|
19726116 |
2009 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report an unusual circumstance where kidneys recovered from a deceased African American male donor with MYH9-related occult FSGS (risk variants in seven of eight MYH9 E1 haplotype single nucleotide polymorphisms) were transplanted into an African American male child with risk variants in four MYH9 E1 risk variants and a European American female teenager with two MYH9 E1 risk variants.
|
19764949 |
2009 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although MYH9 is strongly associated with biopsy-proven idiopathic and HIV-associated focal segmental glomerulosclerosis (FSGS) and clinically diagnosed 'hypertension-associated' end-stage renal disease (ESRD) in African Americans, its role in type 2 diabetes mellitus (T2DM)-associated ESRD is unclear.
|
19567477 |
2009 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As recent studies showed strong association with idiopathic and HIV-related focal segmental glomerulosclerosis and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in this ethnic group, we tested for MYH9 associations in a variety of kidney diseases.
|
19177153 |
2009 |
Focal glomerulosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MYH9 is a podocyte-expressed gene encoding nonmuscle myosin IIA that is associated with idiopathic and human immunodeficiency virus-associated focal segmental glomerulosclerosis (FSGS) and hypertensive end-stage renal disease in African Americans.
|
19153477 |
2009 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.
|
18794856 |
2008 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.
|
18794856 |
2008 |
Focal glomerulosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.
|
18794856 |
2008 |
Focal glomerulosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The AS loci, i.e., COL4A3/COL4A4 and MYH9 (LOD scores: -6.1 and -4.3, respectively) and FSGS loci, on 19q13 and 11q22, were excluded from linkage.
|
12819239 |
2003 |