MYO9B, myosin IXB, 4650

N. diseases: 65; N. variants: 29
Disease: Ulcerative Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Bonferroni correction results showed that rs1545620 A/C polymorphism of MYO9B gene was associated with both CD and UC susceptibility in Caucasians (OR=0.88, 95% CI=0.82∼0.95, P=0.001; OR=0.82, 95% CI=0.76∼0.89, P<0.001), but not in Chinese. rs1457092 G/T and rs2305764 C/T polymorphisms are associated with UC susceptibility (OR=0.85, 95% CI=0.79∼0.91, P<0.001; OR=0.88, 95% CI=0.83∼0.93, P<0.001), but not with CD susceptibility in Caucasians. 27435931 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Polymorphisms in the 3' region of myosin IXB (Myo9B) are associated with chronic inflammatory gastrointestinal disorders like celiac disease and ulcerative colitis, assuming that variation in Myo9B influences the intestinal permeability. 22954106 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02). 21648020 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE A total of 2,049 individuals (656 Crohn's disease [CD], 544 ulcerative colitis [UC], and 849 controls) were genotyped and association studies were performed for 1 single nucleotide polymorphism (SNP) in MAGI2, 1 SNP in PARD3, and 6 SNPs in MYO9B. 21515326 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Analysis of the common MYO9B haplotypes showed significant association for CD and UC alone and IBD overall.No subphenotypic association was found. 19235913 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE MYO9B (myosin IXB) polymorphisms were associated with celiac disease and ulcerative colitis susceptibility, presumably through alteration of the intestinal permeability. 18361936 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Our findings confirm the association between the MYO9B polymorphisms and susceptibility to both ulcerative colitis and Crohn's disease, with a weak influence on sub-phenotypic expression. 17944996 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006