|
hemangiopericytoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion.
|
26746203 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumor is a mesenchymal neoplasm exhibiting a broad spectrum of biological behavior and harboring the NAB2-STAT6 fusion.
|
27562490 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene.
|
28914981 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the <i>NAB2-STAT6</i> fusion gene.
|
29703757 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms.
|
31321477 |
2019 |
|
Malignant neoplasm of prostate
|
0.120 |
PosttranslationalModification
|
disease |
BEFREE |
NAB2 and CDC6 were hypermethylated frequently in pCA (92%, 67%, respectively) and in BPH (91%, 59%, respectively).
|
16956712 |
2007 |
|
Prostate carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
NAB2 and CDC6 were hypermethylated frequently in pCA (92%, 67%, respectively) and in BPH (91%, 59%, respectively).
|
16956712 |
2007 |
|
Hemangiopericytoma of meninges
|
0.020 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases.
|
25893823 |
2015 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases.
|
25893823 |
2015 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 fusion was detected in 34 SFTs.
|
26686340 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NAB2 exon 4-STAT6 exon 3 fusion correlated with classic SFT morphology and older age and showed a trend toward less mitotic activity; there was also a trend toward more aggressive behavior in tumors lacking NAB2 exon 4-STAT6 exon 3.
|
26883114 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity.
|
28128724 |
2017 |
|
hemangiopericytoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity.
|
28128724 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NAB2-STAT6 fusion was detected in 99 of 111 successfully tested tumors (89%) including the single STAT6 immunonegative tumor.
|
30584643 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.
|
30893927 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.
|
30893927 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.020 |
Biomarker
|
disease |
BEFREE |
NAB2 was detected in interstitial CAFs in primary and metastatic lymph node tissues of HNSCC patients.
|
30893927 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
A recurrent intrachromosomal rearrangement on chromosome 12q in solitary fibrous tumor leads to the formation of a NAB2-STAT6 fusion oncogene.
|
24457460 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All tumors were positive for NAB2-STAT6 fusion.
|
27292373 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although weak correlation was found between EGR-1 and NAB-2 expressions on the whole, NAB-2 expression decreased as tumors dedifferentiated, and inhibition of DNA methyltransferase/histone deacetylase increased NAB-2 expression in lung cancer cells despite no epigenetic alteration in the NAB-2 promoter.
|
20489156 |
2010 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
|
23313954 |
2013 |
|
Solitary fibrous tumor
|
0.600 |
FusionGene
|
disease |
ORPHANET |
Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
|
23313954 |
2013 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
CTD_human |
Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
|
23313954 |
2013 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Another useful discovery was that the NAB2-STAT6 fusion is characteristic of solitary fibrous tumors.
|
26811225 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.
|
31424136 |
2020 |