|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we described a cohort of 41 patients with solitary fibrous tumor of the extremities and evaluated the prognostic role of clinical and histological features, presence of C228T and C250T mutations at the TERT promoter region, and NAB2-STAT6 fusion variants.
|
31463729 |
2020 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.
|
31424136 |
2020 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The finding that meningeal solitary fibrous tumors (SFTs) and meningeal hemangiopericytomas (HPCs) are both characterized by NAB2-STAT6 gene fusion has pushed their inclusion in the WHO 2016 Classification of tumors of the central nervous system (CNS) as different manifestations of the same entity.
|
29600523 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT).
|
30664532 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms.
|
31321477 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Most notable classification changes include: adding 'hybrid nerve sheath tumours' to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells.
|
28295484 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene.
|
28914981 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive immunohistochemical stains for CD34 and STAT6 and the detection of NAB2-STAT6 fusion supported the diagnosis of dedifferentiated SFT in both cases.
|
29309807 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, antibodies against the STAT6 C-terminal, are being used in paraffin-embedded tissues as a surrogate for identifying the NAB2-STA6 fusion gene which is considered a specific molecular marker for solitary fibrous tumor.
|
30072169 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the <i>NAB2-STAT6</i> fusion gene.
|
29703757 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies have unraveled STAT6 as a useful diagnostic immunohistochemical (IHC) marker for a SFT and NAB2-STAT6 as its specific gene fusion transcript.
|
28869107 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, an intrachromosomal gene fusion between NAB2 and STAT6 was identified as the defining driving genetic event of SFT and different fusion types correlated with tumor histology and behavior.
|
27292373 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity.
|
28128724 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Solitary fibrous tumor is a mesenchymal neoplasm exhibiting a broad spectrum of biological behavior and harboring the NAB2-STAT6 fusion.
|
27562490 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The clinical aggressiveness of extrathoraic SFTs is associated with malignant histology but unrelated to the NAB2-STAT6 fusion variants.
|
27039712 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, considerable heterogeneity exists in the head and neck SFTs regarding the locations, histological patterns, and NAB2-STAT6 fusion variants.
|
26154686 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NAB2 exon 4-STAT6 exon 3 fusion correlated with classic SFT morphology and older age and showed a trend toward less mitotic activity; there was also a trend toward more aggressive behavior in tumors lacking NAB2 exon 4-STAT6 exon 3.
|
26883114 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Another useful discovery was that the NAB2-STAT6 fusion is characteristic of solitary fibrous tumors.
|
26811225 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
While NAB2:STAT6 fusions are common in solitary fibrous tumors (SFT), we report this event for the first time in a newly diagnosed, secondary-type GBM or any other non-SFT.
|
26817999 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Clinicopathological data, including yearly follow-ups, are required for meningeal SFTs/HPCs to define the correlation of variants of NAB2-STAT6 fusion gene.
|
27271270 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
NAB2-STAT6 fusion was detected in 34 SFTs.
|
26686340 |
2016 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.
|
25582503 |
2015 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast to solitary fibrous tumors of soft tissue and sinonasal tract origin, SN-HPCs were recently shown to lack recurrent NAB2-STAT6 fusion variants.
|
25482924 |
2015 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
FDG PET/CT and MR imaging of CD34-negative soft-tissue solitary fibrous tumor with NAB2-STAT6 fusion gene.
|
25667482 |
2015 |