ATF4, activating transcription factor 4, 468

N. diseases: 178; N. variants: 4
Disease: Mental disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.020 AlteredExpression group BEFREE Together, our study identifies the molecular and structural basis of an DISC1-ATF4 interaction underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. 31444471 2019
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.020 AlteredExpression group BEFREE By showing that DISC1 amino acid substitutions associated with psychiatric illness affect its regulatory function in ATF4-mediated transcription, our study highlights a potential mechanism by which these variants may impact on transcriptional events mediating cognition, emotional reactivity and stress responses, all processes of direct relevance to psychiatric illness. 22422769 2012