NBN, nibrin, 4683

N. diseases: 291; N. variants: 194
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 AlteredExpression group BEFREE In a combined analysis of both treatment arms, high breast tumor p95 content was significantly correlated with trastuzumab treatment benefit in multivariate models (interaction <i>P</i> = 0.01).<b>Conclusions:</b> A high p95HER2/HER2 ratio identified patients with metastatic breast cancer with poor outcomes on trastuzumab-based therapies. 29535130 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN Nijmegen Breakage Syndrome mutations and risk of breast cancer. 17957789 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN NBS1 variant I171V and breast cancer risk. 18049891 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. 17932350 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. 16474176 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women 16714331 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group BEFREE LOH at NBS1 was detected in only 3 of 5 available breast tumors from NBS1 657del5-carriers. 15578693 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN Germline 657del5 mutation in the NBS1 gene in patients with malignant melanoma of the skin. 12883362 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 GeneticVariation group LHGDN Germline 657del5 mutation in the NBS1 gene in breast cancer patients. 12845677 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.100 PosttranslationalModification group LHGDN Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. 12679336 2003