Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Two genes found to be near the top SNPs, CYP19A1 (rs2899472, p = 1.90 × 10(-7)) and NCAM2 (rs1022442, p = 2.75 × 10(-7)) have been reported as genetic factors related to the progression of AD from previous studies.
|
20932310 |
2010 |
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data indicate that Aβ-dependent disruption of NCAM2 functions in AD hippocampus contributes to synapse loss.
|
26611261 |
2015 |
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our reported case raises the questions whether the NCAM2-deletion is the true cause of the ASD or only a risk factor and whether there might be any connection in NCAM2 with skull-size
|
27596683 |
2016 |
Autistic Disorder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
|
27596683 |
2016 |
Autistic Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
The deletion involves 19 genes, including NCAM2 and GRIK1, both of which are associated with normal brain development and function, and have been considered as possible candidate genes in autism and other neurobehavioral disorders.
|
20034085 |
2010 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, NCAM2 should be a novel gene therapy target for the treatment of prostate and breast cancer.
|
21214674 |
2011 |
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, the role of NCAM2 in the pathophysiology of Down syndrome is unknown.
|
9226371 |
1997 |
Complete Trisomy 21 Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Down Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, the role of NCAM2 in the pathophysiology of Down syndrome is unknown.
|
9226371 |
1997 |
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of nine new susceptibility loci for endometrial cancer.
|
30093612 |
2018 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
SNP microarray and whole exome sequencing identified a homozygous frameshift mutation (p.L870V) in SCARF2 and predicted damaging mutations in several genes, most notably DGCR2 (p.P75L) and NCAM2 (p.S147G), both possible candidates for this child's intellectual disability.
|
27375131 |
2016 |
Longevity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Joint influence of small-effect genetic variants on human longevity.
|
20834067 |
2010 |
Longevity
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Joint influence of small-effect genetic variants on human longevity.
|
20834067 |
2010 |
Macrocephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
|
27596683 |
2016 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, NCAM2 should be a novel gene therapy target for the treatment of prostate and breast cancer.
|
21214674 |
2011 |
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer, including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1, RAMP1, TMEM30A, and TMEM66); secreted proteins (SPON2, TMEM30A, TMEM66, and truncated TMEFF2 (called POP4)); intracellular proteins (CAMK2N1, DHCR24, GLO1, NGFRAP1, PGK1, PSMA7, SBDS, and YWHAQ); and noncoding transcripts (POP1 (100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of DSTN), POP10 (intron of ADAM2, accession DO668396), POP11 (87kb from EST BG194644), and POP12 (intron of EST BQ226050)).
|
19893039 |
2009 |
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
Muscular fasciculation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Poor axonal growth and fasciculation is observed in animal models deficient for NCAM2.
|
25464110 |
2015 |
Neurodevelopmental Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders.
|
25464110 |
2015 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study on obesity and obesity-related traits.
|
21552555 |
2011 |