Neurodevelopmental Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders.
|
25464110 |
2015 |
Macrocephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
|
27596683 |
2016 |
Autistic Disorder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
|
27596683 |
2016 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study on obesity and obesity-related traits.
|
21552555 |
2011 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study on obesity and obesity-related traits.
|
21552555 |
2011 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
|
30898391 |
2019 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of nine new susceptibility loci for endometrial cancer.
|
30093612 |
2018 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, the role of NCAM2 in the pathophysiology of Down syndrome is unknown.
|
9226371 |
1997 |
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, the role of NCAM2 in the pathophysiology of Down syndrome is unknown.
|
9226371 |
1997 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, NCAM2 should be a novel gene therapy target for the treatment of prostate and breast cancer.
|
21214674 |
2011 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, NCAM2 should be a novel gene therapy target for the treatment of prostate and breast cancer.
|
21214674 |
2011 |
Longevity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Joint influence of small-effect genetic variants on human longevity.
|
20834067 |
2010 |
Longevity
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Joint influence of small-effect genetic variants on human longevity.
|
20834067 |
2010 |
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer, including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1, RAMP1, TMEM30A, and TMEM66); secreted proteins (SPON2, TMEM30A, TMEM66, and truncated TMEFF2 (called POP4)); intracellular proteins (CAMK2N1, DHCR24, GLO1, NGFRAP1, PGK1, PSMA7, SBDS, and YWHAQ); and noncoding transcripts (POP1 (100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of DSTN), POP10 (intron of ADAM2, accession DO668396), POP11 (87kb from EST BG194644), and POP12 (intron of EST BQ226050)).
|
19893039 |
2009 |
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer, including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1, RAMP1, TMEM30A, and TMEM66); secreted proteins (SPON2, TMEM30A, TMEM66, and truncated TMEFF2 (called POP4)); intracellular proteins (CAMK2N1, DHCR24, GLO1, NGFRAP1, PGK1, PSMA7, SBDS, and YWHAQ); and noncoding transcripts (POP1 (100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of DSTN), POP10 (intron of ADAM2, accession DO668396), POP11 (87kb from EST BG194644), and POP12 (intron of EST BQ226050)).
|
19893039 |
2009 |
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data indicate that Aβ-dependent disruption of NCAM2 functions in AD hippocampus contributes to synapse loss.
|
26611261 |
2015 |
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our reported case raises the questions whether the NCAM2-deletion is the true cause of the ASD or only a risk factor and whether there might be any connection in NCAM2 with skull-size
|
27596683 |
2016 |
Down Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Complete Trisomy 21 Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that synapse maturation is inhibited in NCAM2-overexpressing neurons and suggest that changes in NCAM2 levels and altered submembrane Ca2+ dynamics can cause defects in synapse maturation in Down syndrome and other brain disorders associated with abnormal NCAM2 expression.
|
29522129 |
2019 |
Muscular fasciculation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Poor axonal growth and fasciculation is observed in animal models deficient for NCAM2.
|
25464110 |
2015 |