ATM, ATM serine/threonine kinase, 472

N. diseases: 684; N. variants: 974
Disease: Tooth Attrition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004277
Disease: Tooth Attrition
Tooth Attrition 		0.020 Biomarker disease BEFREE In an attempt to minimize attrition during clinical development, we sought to identify ATM inhibitors with a low predicted clinical dose (<50 mg) and focused on strategies to increase both ATM potency and predicted human pharmacokinetic half-life (predominantly through the increase of volume of distribution). 29683659 2018
CUI: C0004277
Disease: Tooth Attrition
Tooth Attrition 		0.020 Biomarker disease BEFREE Dysfunctional ATM appears inefficient in alleviating elevated redox burdens and telomere attrition and in evoking a p53-dependent apoptotic response to genotoxic insults. 29449575 2018