|
Glioblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.
|
30783513 |
2019 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
It has been shown that pharmacological inhibition of ATM protein may overcome the DDR-mediated resistance in GICs and significantly radiosensitize GIC-driven GB.
|
31092378 |
2019 |
|
Glioblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our study outlined the immunohistochemical expression of p-ATM/p53 in glioblastomas and provided data on their possible prognostic/predictive of response role.
|
29369420 |
2018 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Ablation of the Ataxia-telangiectasia mutated serine/threonine kinase that is recruited and activated by DNA double-strand breaks reverses the effect of radioresistance and re-sensitised GBM to DNA damage thus leading to increase cell death.
|
29564746 |
2018 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
H1/pHGFK1 exerts anti-tumoural and radiosensitive activities mainly through the inhibition and reversal of IR-induced MET and ATM-Chk2 axis activities in glioblastoma.
|
29348487 |
2018 |
|
Glioblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Exome sequencing of GBM CTC clusters highlights variants in 58 cancer-associated genes including ATM, PMS2, POLE, APC, XPO1, TFRC, JAK2, ERBB4 and ALK.
|
30065256 |
2018 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Knockout of ATM expression and inhibition of ATM function in GBM cell lines inhibited cell proliferation and migration, increased sensitivity to apoptosis induced by therapeutic agents <i>in vitro</i>, and markedly suppressed GBM tumor growth and promoted animal survival.
|
29348882 |
2017 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.
|
26984279 |
2016 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Higher biological effects in the cells irradiated with soft X-rays at 2153 eV than at 2147 eV were observed in (i) the efficiency of 53BP1/γ-H2AX co-localized foci formation per dose and residual number of foci, (ii) prolonged phosphorylation levels of DSB repair and/or cell cycle checkpoint related proteins and G2 arrest, (iii) the cell killing effects at the 10% survival level of normal human fibroblasts, HeLa cells, and human glioblastoma M059K cells (1.2-1.5 times higher) and that of human ataxia telangiectasia mutated (ATM)-defective cells and glioblastoma DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-defective cells (1.2 times).
|
27185241 |
2016 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.
|
24991884 |
2015 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we tested whether NVP-BEZ235 could also inhibit ATM and DNA-PKcs in tumors in vivo and assessed its potential as a radio- and chemosensitizer in preclinical mouse glioblastoma models.
|
24366691 |
2014 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of 7 biomarkers on a series of 21 PIGCTs (germinomas and other subtypes), 20 normal brain specimens and 20 glioblastomas, revealed the following: i) The overall DDR signaling (γH2AX) and activation of the ATM-Chk2-p53 pathway were very low among the PIGCTs, reminiscent of TGCTs, and contrasting sharply with strong DDR activation in glioblastomas; ii) Except for one case of embryonal carcinoma, there were no clear aberrations in the ATM-Chk2-p53 pathway components among the PIGCT cohort; iii) Subsets of PIGCTs showed unusual cytosolic localization of Chk2 and/or ATM.
|
25066726 |
2014 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
|
23960094 |
2013 |
|
Glioblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since ATM induces cell cycle arrest or apoptosis through cell cycle regulators in response to genotoxic insults, these results indicate that aberrant DDR signaling through ATM in GBM may be associated with resistance to genotoxic anti-tumor therapeutics.
|
21617879 |
2011 |
|
Glioblastoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Six hundred and eighty glioma cases (298 glioblastoma (GBM)), 503 meningioma cases, and 1555 controls recruited in the Nordic-UK Interphone study, were analysed in association with three polymorphisms in p53 (rs2287499, rs1042533, rs1625895) and five polymorphisms in ATM ( rs228599, rs3092992, rs664143, rs170548, rs3092993).
|
17151932 |
2007 |
|
Glioblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Intrinsic cellular radiosensitivity of 22 colorectal and glioblastoma cell lines fall into four radiosensitivity groups that associate with expression of ATM and TP53.
|
17562439 |
2007 |
|
Glioblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study found both positive and negative associations of haplotypes in p53 for glioblastoma and ATM for meningioma.
|
17151932 |
2007 |
|
Glioblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We attenuated ATM protein expression in human glioblastoma cells by expressing antisense RNA to a functional domain of the atm gene.
|
10845723 |
2000 |
|
Glioblastoma
|
0.200 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|