|
leukemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Inhibition of novel GCN5-ATM axis restricts the onset of acquired drug resistance in leukemia.
|
29297932 |
2018 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
RGD |
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
|
28007901 |
2017 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline Genetic Predisposition to Hematologic Malignancy.
|
28297620 |
2017 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias.
|
27625305 |
2016 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Both A-T and T-cell prolymphoblastic leukemia patients with somatic mutations of ATM frequently carry inv(14;14) between the T-cell receptor α/δ (TCRα/δ) and immunoglobulin H loci, but the molecular origin of this translocation remains elusive.
|
25721125 |
2015 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), a complex neurological disease associated with a high risk of leukaemias and lymphomas.
|
19404735 |
2010 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias.
|
17516749 |
2007 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We show that the residual ATM allele is mutated in 36% of CLLs with an 11q deletion and that these leukemias demonstrate an impaired cellular response to irradiation or cytotoxic drug exposure in vitro.
|
17968022 |
2007 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.
|
17030982 |
2006 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
ATM mutations have been reported in adult sporadic lymphoma and leukaemia.
|
14735203 |
2004 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis.
|
14628072 |
2004 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our finding in this patient suggests that altered function of ATM plays some pathogenic roles in the development of MLL(+) leukemia.
|
12511424 |
2003 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Our finding in this patient suggests that altered function of ATM plays some pathogenic roles in the development of MLL(+) leukemia.
|
12511424 |
2003 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This, coupled with a possibly increased risk of leukaemia in relatives of patients with Ataxia Telangiectasia, led us to question whether the ATM gene is involved in familial cases of CLL.
|
10516748 |
1999 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of heterozygosity at 11q22-23 and ATM mutations in leukemias carrying TCL-1 rearrangements.
|
9892178 |
1999 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
T-prolymphocytic leukaemia (T-PLL) is a rare, sporadic leukaemia similar to a mature T-cell leukaemia seen in some patients with Ataxia Telangiectasia (A-T), a recessive multisystem disorder caused by mutations of the ATM gene at chromosome 11q23.
|
9488043 |
1998 |
|
leukemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The absence of somatic nucleotide changes in ATM in T-ALL as compared with T-PLL suggests a distinct pattern of genetic events in the development of the two leukemias.
|
9622061 |
1998 |
|
leukemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer.
|
9463314 |
1998 |
|
leukemia
|
0.900 |
CausalMutation
|
disease |
CGI |
|
|
|
|
leukemia
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
leukemia
|
0.900 |
GenomicAlterations
|
disease |
CGI |
|
|
|