ATM, ATM serine/threonine kinase, 472

N. diseases: 684; N. variants: 974
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease BEFREE In the study the modulating effect of inhibition of phosphatidylinositol 3-kinase-related kinases (PIKK): ATM (Ataxia Telangiectasia Mutated), ATR (Ataxia Telangiectasia and Rad3 Related) and DNA-PK (DNA-dependent protein kinase) on genotoxicity of dibenzo[def,p]chrysene (DBC) in HepG2 human hepatocellular cancer cells was investigated. 31838185 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease BEFREE Hence, in the present study the components of the DNA damage response (DDR) pathway were examined; ATM, p53, and MDM4 in FL‑HCC. 31322272 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease BEFREE Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells. 28638267 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease BEFREE The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2. 26595742 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 AlteredExpression disease BEFREE In cultured HuH-7 cell line derived from human hepatocellular carcinoma, cis-platinum, acetaminophen, or hydrogen peroxide caused DNA strand breaks and ATM pathway activation as shown by γH2AX expression, which in turn, led to rapid and sustained increases in ATM promoter activity. 24927134 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 GeneticVariation disease BEFREE High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, ARID2, MLL, MLL2, MLL3, MLL4, IRF2, ATM, CDKN2A, FGF19, PIK3CA, RPS6KA3, JAK1, KEAP1, NFE2L2, C16orf62, LEPR, RAC2, and IL6ST. 24379610 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease CTD_human Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. 19919837 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 AlteredExpression disease BEFREE The effects of different steroids on the expression of angiotensin AT1 receptors by the human hepatoma cell line, PLC-PRF-5 was studied. 7774681 1995