|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
NRP-2 expression was observed in the endothelium and was similar across all three cancer grades.
|
30806307 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
NRP-2 expression was observed in the endothelium and was similar across all three cancer grades.
|
30806307 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
NRP-2 in tumor lymphangiogenesis and lymphatic metastasis.
|
29339213 |
2018 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Therefore, it is necessary for us to develop an affinity reagent for noninvasive imaging of NRP‑2 expression because it may be possible to provide early cancer diagnosis, more accurate prognosis, and better treatment planning.
|
28000859 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Nrp-2, expressed on both tumor and LECs, may have a mechanistic role in lymphatic invasion and is a potential novel target in CRC.
|
28742689 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In conclusion, this study demonstrates that 131I‑anti‑NRP‑2 mAb exhibited highly selective uptake in NRP‑2‑expressing tumors, and may provide a promising SPECT probe for imaging NRP‑2 positive tumors.
|
28000859 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Therefore, it is necessary for us to develop an affinity reagent for noninvasive imaging of NRP‑2 expression because it may be possible to provide early cancer diagnosis, more accurate prognosis, and better treatment planning.
|
28000859 |
2017 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Although the osteogenic effects of NELL1 and functions of NELL2 in neural development have been reported, their expression and functions in cancer are largely unknown.
|
25726761 |
2015 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Although the osteogenic effects of NELL1 and functions of NELL2 in neural development have been reported, their expression and functions in cancer are largely unknown.
|
25726761 |
2015 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Together, these data suggest a link between the VEGF-C/NRP-2 axis and cancer cell survival despite the presence of chemotherapy-induced stress.
|
23149913 |
2013 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Together, these data suggest a link between the VEGF-C/NRP-2 axis and cancer cell survival despite the presence of chemotherapy-induced stress.
|
23149913 |
2013 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, our results demonstrate that tumor cell-derived NRP-2 mediates critical survival signaling in gastrointestinal cancer cells.
|
22028766 |
2011 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Using mRNA expression profiles retrieved from microarrays deposited in the Gene Expression Omnibus Profiles database, RT-qPCR measurement and bioinformatics analysis, we further indicated that high expression of HBB might predict a poorer 5-year survival, high expression of ALDH1A2 and ABCA8 might predict a poor outcome; while ALDH1A2, ADH1B, HBB and ABCA8, in particular the former two genes, might be associated with drug resistance, and ALDH1A2 and NELL2 might contribute to invasiveness and metastasis in ovarian cancer.
|
25891226 |
2015 |
|
Dermatitis, Atopic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, genes known to be specifically expressed in epidermis of patients with AD such as CAII and NELL2 were induced.
|
21514424 |
2011 |
|
Eczema
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, genes known to be specifically expressed in epidermis of patients with AD such as CAII and NELL2 were induced.
|
21514424 |
2011 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Focused gene-array analysis demonstrated that loss of NRP-2 reduced the expression of a critical metastasis mediator gene, S100A4.
|
22028766 |
2011 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In CNDT 2.5 cells, shRNA mediated knockdown NRP-2 expression led to decreased migration and invasion in vitro (p<0.01).
|
22028766 |
2011 |
|
Dermatitis, Atopic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Remarkably, the presumed neuron-specific Nel-like protein 2 showed a strong induction only in AD epidermis.
|
19818069 |
2010 |
|
Eczema
|
0.020 |
Biomarker
|
disease |
BEFREE |
Remarkably, the presumed neuron-specific Nel-like protein 2 showed a strong induction only in AD epidermis.
|
19818069 |
2010 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Although mRNA for VEGF121, VEGF165, VEGFR-1 and NRP-2 was widely expressed, mRNA expression for VEGF189, VEGFR-2 and NRP-1 was linked to a malignant phenotype such as local invasion.
|
15868933 |
2005 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of NRP-1 and NRP-2 in Endometrial Cancer.
|
30806307 |
2019 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of NRP-1 and NRP-2 in Endometrial Cancer.
|
30806307 |
2019 |
|
Lymphatic Metastasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NRP-2 in tumor lymphangiogenesis and lymphatic metastasis.
|
29339213 |
2018 |