NFATC1, nuclear factor of activated T cells 1, 4772

N. diseases: 161; N. variants: 23
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE Therefore, inhibition of the interplay between PIM kinases and NFATC1 may have therapeutic implications for patients with metastatic forms of cancer. 31730483 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE These data underline the indispensability of NFATc1 for successful antitumor immune responses in patients with NSCLC.<b>Significance:</b> The multifaceted role of NFATc1 in the activation and function of T cells during lung cancer development makes it a critical participant in antitumor immune responses in patients with NSCLC.<i>Cancer Res; 78(13); 3619-33.©2018 AACR</i>. 29691251 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE It has been reported that nuclear factor of activated T cells (NFATC1) was up-regulated in cancers mediating malignant behaviors. 26501422 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE NFATc1 (nuclear factor of activated T‑cells c1) is associated with malignancy in several cancer models. 27350254 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE Our results demonstrated that the expression of CA-NFATc1 promoted cancer cell invasion, while small interfering RNA (siRNA) against NFATc1 successfully inhibited the invasion ability of the U251 cell line. 25738651 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE The role of increased NFATc1 expression on the growth inhibitory effect of P-S on cancer growth was evaluated by silencing or by overexpressing it both in vitro and in vivo. 24284479 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE The expression of NFATc1CA promoted cancer cell invasion in association with changes in cell morphology. 23811942 2013