Hypertensive disease
|
0.300 |
Therapeutic
|
group |
RGD |
Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress.
|
23775684 |
2014 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
The aim of this study was to investigate the renoprotective effect of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator with an antioxidant effect, in a salt-sensitive hypertension model induced by aldosterone (Ald) and salt.
|
28978980 |
2018 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice.
|
29211853 |
2018 |
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Combined polymorphisms of three NRF2-regulated genes increased risk of DM and hypertension.
|
31332605 |
2020 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These results suggest that activation of the Nrf2 pathway promotes antioxidant effects of nitrite, which may improve the vascular dysfunction in hypertension, even when nitrite is given at a sub-antihypertensive dose.
|
31251976 |
2019 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Collectively, these results suggested that miR‑140‑5p aggravated hypertension and oxidative stress of mice with atherosclerosis by targeting Nrf2 and Sirt2.
|
30483753 |
2019 |
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Together these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1β-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation.
|
27223823 |
2016 |
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that PVN administration of tBHQ can attenuate hypertension by activation of the Nrf2-mediated signaling pathway.
|
28842207 |
2017 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
In conclusion, tBHQ activates Nrf2 to prevent microvascular endothelial dysfunction, remodeling, and contractility, and moderate ADMA and hypertension at 12-14 days of ANG II infusion, thereby preserving endothelial function and preventing hypertension.
|
29167164 |
2018 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways.
|
28906458 |
2017 |
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
NRF2 polymorphism rs6721961 showed association with hypertension.
|
27226772 |
2016 |
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
In conclusion, maternal Nrf2 activation by DMF protects male adult offspring against hypertension programmed by combined DEX and HF exposures.
|
31416234 |
2019 |