NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE Combined polymorphisms of three NRF2-regulated genes increased risk of DM and hypertension. 31332605 2020
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE These results suggest that activation of the Nrf2 pathway promotes antioxidant effects of nitrite, which may improve the vascular dysfunction in hypertension, even when nitrite is given at a sub-antihypertensive dose. 31251976 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE Collectively, these results suggested that miR‑140‑5p aggravated hypertension and oxidative stress of mice with atherosclerosis by targeting Nrf2 and Sirt2. 30483753 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE In conclusion, maternal Nrf2 activation by DMF protects male adult offspring against hypertension programmed by combined DEX and HF exposures. 31416234 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE The aim of this study was to investigate the renoprotective effect of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator with an antioxidant effect, in a salt-sensitive hypertension model induced by aldosterone (Ald) and salt. 28978980 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice. 29211853 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE In conclusion, tBHQ activates Nrf2 to prevent microvascular endothelial dysfunction, remodeling, and contractility, and moderate ADMA and hypertension at 12-14 days of ANG II infusion, thereby preserving endothelial function and preventing hypertension. 29167164 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 AlteredExpression group BEFREE These findings suggest that PVN administration of tBHQ can attenuate hypertension by activation of the Nrf2-mediated signaling pathway. 28842207 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways. 28906458 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE Together these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1β-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation. 27223823 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE NRF2 polymorphism rs6721961 showed association with hypertension. 27226772 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Therapeutic group RGD Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress. 23775684 2014