Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that the therapeutic effect of trichostatin A on Alzheimer's disease is associated with the Keap1-Nrf2 pathway.
|
31552902 |
2020 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
At present, this article reviews this relationship from these aspects: (a) the signaling pathways of regulating autophagy; (b) the relationships between the autophagy and the processing of Aβ; (c) Aβ and Tau cause autophagy dysfunction; (d) normal autophagy promotes the clearance of Aβ and Tau; (e) the relationships between the autophagy and both genes and proteins related to AD: TFEB, miRNAs, Beclin-1, Presenilin, and Nrf2; and (f) the small molecules regulating autophagy on AD therapy.
|
31503421 |
2020 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We report here that the activation of NRF2 pathway reduces amyloid secretion, normalizes cytokine release, and increases GSH secretion in AD astrocytes.
|
31670864 |
2020 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of the Nrf2/ARE signaling pathway may underlie the protective effects of edaravone against the oxidative damage associated with Alzheimer's disease.
|
30769116 |
2019 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L-Tg mouse model of Alzheimer's disease through modulation of oxidative stress.
|
30461032 |
2019 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Indeed, altered Nrf2 activity is involved in aging and NDD, such as AD and PD.
|
31415806 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Protective roles of Amanita caesarea polysaccharides against Alzheimer's disease via Nrf2 pathway.
|
30290256 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease.
|
30725250 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
This review will focus on the NRF2 pathway and the role of NRF2 in AD and suggest some NRF2 inducers as therapeutic agents for AD.
|
30617737 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data provide a novel insight into the molecular mechanism that impairments of Nrf2-TXNIP-TrX system may be involved in the imbalance of cellular redox homeostasis and inflammatory damage in the AD brain.
|
29634349 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis.
|
30664148 |
2019 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that activation of NRF2 can prevent a key early pathogenic process in AD.
|
31164420 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
We have reported that CA water extract (CAW) treatment improves cognitive function of aged Alzheimer's disease (AD) model Tg2576 and wild-type (WT) mice, and induces an NRF2-regulated antioxidant response in aged WT mice.
|
31817977 |
2019 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Noncovalent inhibitors of the Keap1-Nrf2 protein-protein interaction (PPI) have therapeutic potential in a range of disease states including neurodegenerative diseases (Parkinson's and Alzheimer's diseases), chronic obstructive pulmonary disease and various inflammatory conditions.
|
29927029 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
As such, Nrf2 deregulation has been linked to both aging and pathogenesis of many human chronic diseases, including neurodegenerative ones such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis.
|
29969760 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Transcripts of the transcription factor NFE2L2 and inducible HMOX1, were also increased in the AD-STG, and this corresponded to increased Nuclear factor erythroid 2-related factor (NRF-2) and total heme-oxygenase (HO) activity.
|
30068908 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway.
|
30090650 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we discovered a BBB-bypassing Nrf2-activating polysaccharide that may attenuate AD pathogenesis.
|
30282635 |
2018 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease.
|
28887195 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results support a possible role for age-related Nrf2 dysfunction in the pathogenesis of vascular cognitive impairment and Alzheimer's disease.
|
29905772 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recently, nuclear factor E2-related factor 2 (Nrf2) has emerged as a master regulator for the endogenous antioxidant response, and thus represents an attractive therapeutic target against AD.
|
29555592 |
2018 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our results confirm that SFN has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies and AD-like pathological lesions related to the upregulation of Nrf2-regulated antioxidant defenses.
|
29684505 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
AF exerts a protective effect against Aβ<sub>1-42</sub>-induced neurotoxcicity by inducing Nrf2 antioxidant pathways via AMPK signaling activation, which provided experimental evidence that AF might provide a clinical benefit to patients with AD.
|
29411261 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results suggest that the anti-AD effect of pyridoxine may be attributed to its anti-oxidant property elicited via stimulation of the Nrf2/HO-1 pathway.
|
30084803 |
2018 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates the relevance of the inflammatory response in experimental AD, tightly regulated by NRF2 activity, and provides a new strategy to fight AD.
|
30029164 |
2018 |