NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Disease: Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.040 AlteredExpression group BEFREE Immunohistochemistry showed increased Nrf2 expression in nuclei of all mutated carcinomas, which presented poor prognostic features in histopathology. 29469959 2018
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.040 Biomarker group BEFREE In order to clarify the role of p62/SQSTM1 in carcinogenesis in oral epithelium, both p62/SQSTM1 and Nrf2 were immunohistochemically evaluated in 54 carcinomas and 14 low grade dysplasias. p62/SQSTM1 knockdowns were also designed in oral cancer cells, and we analyzed the Nrf2 pathway, GSH contents and ROS accumulation. 24086340 2013
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.040 GeneticVariation group BEFREE MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas. 22767273 2012
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.040 GeneticVariation group BEFREE Somatic mutation of NRF2 and KEAP1 genes and loss of KEAP1 expression are detected in many carcinomas and contribute to cancer development. 23052169 2012