|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
FSGHF3 and peptides, prepared from fish skin gelatin, exert a protective effect on DSS-induced colitis via the Nrf2 pathway.
|
31825438 |
2020 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data for the first time confirmed that the maggot extracts ameliorated inflammation and oxidative stress in experimental colitis via modulation of the Nrf2/HO-1 pathway.
|
31827675 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the roles of Nrf2 in the development of colitis-associated colorectal cancer (CACC) have not been well characterized.
|
31628914 |
2019 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO-1 pathway.
|
30426485 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation.
|
31534619 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reciprocal activations of inflammatory and antioxidative defense signaling after DSS administration might be prerequisite to make intestinal homeostasis and host defense Nrf2 system can determine colitis.
|
30683827 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate the possible involvement of Nrf2-mediated upregulation of P-gp in the therapeutic effect of berberine on colitis and highlight the potential of P-gp and/or Nrf2 as new therapeutic targets for IBD.
|
29891588 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
|
30284461 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we identified a novel effective Nrf2 activator, DDO7232, which showed protective effects on NCM460 cells and therapeutic effects on DSS-induced colitis in mice.
|
29887940 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ability of standard (St) or cow milk naturally-enriched in RA (En) to activate Nrf2 pathway and its impact on dextran sodium sulfate (DSS)-induced colitis was comparatively evaluated.
|
28987717 |
2017 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now demonstrate that colonic tissue from Ier3(-/-) mice subject of dextran sodium sulfate colitis exhibit greater Nrf2 activity than Ier3(+/+) mice, manifesting as increased nuclear Nrf2 protein level and Nrf2 target gene expression.
|
24311782 |
2014 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PHB Tg/Nrf2(-/-) mice exhibited increased activation of ERK during colitis.
|
23494124 |
2013 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found that treatment with AcEGCG increased heme oxygenase-1(HO-1) expression via activation of extracellular signal-regulated protein kinase (ERK)1/2 signaling and acetylation of NF-E2-related factor 2 (Nrf2), thereby abating DSS-induced colitis.
|
22409325 |
2012 |
|
Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PHB transgenic mice exhibited decreased oxidative stress and colitis and increased Nrf2 messenger RNA expression, nuclear protein translocation, and DNA binding compared with wild-type littermates during colitis.
|
19327358 |
2009 |