NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Disease: Acute monocytic leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 Biomarker disease BEFREE The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML. 30623427 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 AlteredExpression disease BEFREE AML cell lines stably overexpressing NRF2 showed increased resistance to ATO, Dnr and Ara-C and increased expression of downstream targets. 28505160 2017
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 AlteredExpression disease BEFREE NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. 25323587 2015