|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although small airway lesions and emphysema contribute cooperatively to airflow limitation, the relationship between Nrf2 SNPs and the development of emphysema in smokers without COPD is not well understood.
|
31297601 |
2019 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the emphysema suppression effect of astaxanthin via Nrf2 in mice.
|
31795292 |
2019 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we examined the emphysema suppressive effects of the exercise-irisin-Nrf2 axis in mice.
|
31814716 |
2019 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, it remains elusive whether Wnt/β-catenin and AMPK modulate nuclear factor erythroid-2 related factor-2 (Nrf2)-mediated protective responses during the development of emphysema.
|
29659176 |
2018 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways.
|
28347799 |
2017 |
|
Pulmonary Emphysema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2.
|
28886998 |
2017 |
|
Pulmonary Emphysema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We verified using the preclinical COPD-emphysema murine model that chronic CS (Ch-CS)-induced inflammation (interleukin [IL]-6/IL-1β levels), aggresome formation (perinuclear coexpression/colocalization of ubiquitinated proteins [Ub] and p62 [impaired autophagy marker], and CFTR), oxidative/nitrosative stress (p-Nrf2, inducible nitric oxide synthase [iNOS], and 3-nitrotyrosine expression), apoptosis (caspase-3/7 activity), and alveolar airspace enlargement (Lm) are significantly (p < 0.05) alleviated by augmenting airway GSNO levels.
|
28006950 |
2017 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inadequacy of antioxidant nuclear factor-E2-related factor 2 (Nrf2) and endoplasmic reticulum stress-mediated unfolded protein response has been implicated in severe chronic obstructive pulmonary disease (COPD) and cigarette smoking-induced emphysema.
|
27555763 |
2016 |
|
Pulmonary Emphysema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using mice with targeted deletion of Nrf2, a protective role for this transcription factor has been determined in many model diseases, including acute lung injury, emphysema, allergy and asthma, pulmonary fibrosis, and respiratory syncytial virus disease.
|
24783956 |
2014 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the basis of the fundamental significance of the Nrf2 pathway in smoking-dependent disease development, several attempts have been described for dietary and pharmacological intervention, the majority of which are intended to activate Nrf2 aiming at emphysema prevention.
|
22686525 |
2012 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified that VCP also mediates proteasomal degradation of HDAC2 and Nrf2, as a potential mechanism for increased oxidative stress and corticosteroid resistance in COPD subjects with emphysema.
|
21318260 |
2011 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema.
|
19671143 |
2009 |
|
Pulmonary Emphysema
|
0.100 |
Biomarker
|
disease |
BEFREE |
The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke-induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis.
|
15520857 |
2004 |