NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE We also aimed to examine the role of Nrf2 activation in modulating the response to sepsis following BMSCs treatment. 30250973 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 AlteredExpression disease BEFREE Rational cyclization-based minimization of entropy penalty upon the binding of Nrf2-derived linear peptides to Keap1: A new strategy to improve therapeutic peptide activity against sepsis. 30465941 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE These data reveal that H<sub>2</sub> gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H<sub>2</sub> gas on lung damage caused by sepsis. 30660872 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 AlteredExpression disease BEFREE In the sepsis group, the structure of myocardial tissue and mitochondria were significantly damaged, the serum cTnI level increased (<i>P</i> < 0.05), the ATP level reduced, the degree of myocardial mitochondrial swelling aggravated, and the mRNA expression levels of Nrf2, PGC-1α, and Tfam increased (<i>P</i> < 0.05). 29887956 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Our study establishes Nrf2 as key regulator of MDSCs and acquired tolerance against LPS-induced sepsis. 30034396 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis. 27899278 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Amentoflavone prevents sepsis-associated acute lung injury through Nrf2-GCLc-mediated upregulation of glutathione. 27718499 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 AlteredExpression disease BEFREE Next, the role of Nrf2/HO-1 was investigated in activated HUVECs, as well as in wild-type and Nrf(-/-) mice with sepsis. 26253656 2015
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE NF-E2-related factor 2 (Nrf2) has been demonstrated to be a key transcription factor regulating the anti-inflammatory genes including heme oxygenase-1 (HO-1) in experimental sepsis models. 24474616 2014
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Nuclear factor erythroid 2-related factor 2 (NRF2) has been shown to protect against experimental sepsis in mice and lipopolysaccharide (LPS)-induced inflammation in ex vivo white blood cells from healthy subjects by upregulating cellular antioxidant genes. 25105464 2014
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Nfe2l2(-/-) mice in sepsis also generated higher hepatic TNF-α mRNA levels, lower NRF-1 and PGC-1α mRNA levels, and no enhancement of anti-inflammatory Il10, Socs3, or bcl-x(L) gene expression. 21454555 2011
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis. 18981090 2008
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Mouse studies have demonstrated a critical role of Nrf2 in improving survival during sepsis. 17822364 2007