|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we provide genetic evidence that concurrent activation of NF-kB and Notch signaling in committed B cells is sufficient to induce B cell lymphomatous transformation and primes common progenitor cells to convert to myeloid lineage through dedifferentiation, not transdifferentiation.
|
31697816 |
2020 |
|
Endometrioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data identify differentially expressed proteins S100A9 and S100A8, and suggest they may serve as novel molecular markers to predict postoperative recurrence of an ovarian endometriotic cysts.<b>Abbreviations:</b> iTRAQ: isobaric tags for relative and absolute quantitation; HPRD: Human Protein Reference Database; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; EM: Endometriosis; COX-2: cyclooxyenase-2; NF-kB: nuclear factor kappa-B; PR-B: progesterone receptor type B.
|
31714804 |
2020 |
|
Attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, the current study investigated P50 suppression in young adolescents (12-17 years old) with either EOP (N = 55) or ADHD (N = 28) and age and gender matched healthy controls (HC) (N = 71).
|
31649298 |
2020 |
|
Acquired Immunodeficiency Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
The protein expression levels of RAS, RAF, nuclear factor (NF)-κB P65 and P50 as well as inhibitor of NF-κB-α of the TLR4 signaling pathway in AIDS-KS and KS tissues were higher than those in normal tissues.
|
30651761 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, these agents decreased the activity of MPO (<i>p</i> ˂ .001), TNF-α (<i>p</i> ˂ .001) and the expression level of p-NF-kB (<i>p</i> ˂ .001) in rat colon tissue compared with the acetic acid group.<b>Conclusion:</b> It is proposed that the anti-inflammatory activity of dapsone on acetic acid-induced colitis in rats may involve the inhibition of NF-kB pathway.
|
31621446 |
2019 |
|
Drug abuse
|
0.010 |
Biomarker
|
group |
BEFREE |
In the version of this Comment originally published, the authors omitted a funding source.Grant 5 P50 DA039841 (to E.J.C.) from the US National Institute on Drug Abuse has been added to the Acknowledgements in the HTML and PDF versions of the paper.
|
30584248 |
2019 |
|
Drug habituation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In two distinct auditory paradigms sensory gating, indexed as P50 suppression, and sensorimotor gating, indexed as prepulse inhibition (PPI), startle reactivity, and habituation of the eye-blink startle response were examined.
|
29769152 |
2019 |
|
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The effect of PGB on CYP-induced mechanical referred hyperalgesia (abdominal Von Frey test), inflammation (organ weight, cytokine production, α<sub>2</sub>δ subunit level, NF-kB pathway activation) were assessed 1 h after its injection.
|
30863309 |
2019 |
|
Spinal Muscular Atrophy
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, we uncovered that β2-adrenergic signaling positively modulates expression as well as phosphorylation of p50 and p65 in SMA mouse DRGs.
|
31019235 |
2019 |
|
Ocular Hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, the mean P50 and N95 amplitude were significantly lower in the POAG group and the OHT group compared with the control group (P<0.001,<0.001, respectively).
|
31306362 |
2019 |
|
Pemphigus Vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of NFKB1 -94ATTG ins/del polymorphism (rs28362491) with pemphigus vulgaris.
|
31077459 |
2019 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition.
|
31323300 |
2019 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion</b>: The <i>NF-κB1-</i>94ins/del ATTG polymorphism is an independent risk factor for essential hypertension.
|
30285510 |
2019 |
|
Adenomatoid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors.
|
30171198 |
2019 |
|
Uveal melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Activation of NFκB1/p50 was evaluated in 75 cases of uveal melanoma by immunohistochemistry. mRNA expression in 58 fresh UM specimen was measured by quantitative reverse-transcriptase PCR (qRT-PCR).
|
31533021 |
2019 |
|
Kaposi's sarcoma classical type
|
0.010 |
Biomarker
|
disease |
BEFREE |
The protein expression levels of RAS, RAF, nuclear factor (NF)-κB P65 and P50 as well as inhibitor of NF-κB-α of the TLR4 signaling pathway in AIDS-KS and KS tissues were higher than those in normal tissues.
|
30651761 |
2019 |
|
Primary central nervous system lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Two such genes, MYD88 and CD79B, implicate the involvement of the NF-kB (nuclear factor kappa-light-chain enhancer of activated B cells) pathway, and targeted agents to this pathway are currently being used in the treatment of relapsed/refractory PCNSL.
|
31592789 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Impact of neonatal malnutrition on expression TLR-9, NF-kB and cytokines of macrophages infected in vitro with methicillin resistant Staphylococcus aureus.
|
31075429 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings suggested that a decrease of brain Pls can activate the NF-kB, p38MAPK and JNK pathways to induce a prolonged microglial activation which may downplay the neuroprotective events in the brains of neurodegenerative diseases.
|
30496826 |
2019 |
|
Acute central serous chorioretinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Between the baseline P50 amplitude and the visual acuities of the affected eyes, a strong correlation was noted at baseline (r = -0.691, p < 0.001) and a moderate correlation was noted after CSCR resolution (r = -0.422, p = 0.031).
|
31822040 |
2019 |
|
Acute GVH disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NF-κB1 genotype and cytomegalovirus infection were significantly associated with risk of aGVHD II-IV (p = 0.022, HR = 3.17, 95 % CI:1.18-8.51 and p = 0.048, HR = 2.56, 95 % CI:1.01-6.52, respectively).
|
31813598 |
2019 |
|
Drug-Induced Liver Disease
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.
|
31490979 |
2019 |
|
Spondylarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Local ice cryotherapy significantly reduced the IL-6, IL-1β, VEGF, NF-kB-p65, and PG-E2 synovial levels, especially in the microcrystal-induced arthritis subgroup, while only phosphorylated NF-kB-p65 significantly decreased in rheumatoid arthritis and spondyloarthritis patients.
|
31362785 |
2019 |
|
Infantile malignant osteopetrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NF-κB1 (p50) and NF-κB2 (p52) double-knockout mice exhibited severe osteopetrosis due to the total lack of osteoclasts, suggesting that NF-κB activation is required for osteoclast differentiation.
|
31847314 |
2019 |
|
Well-differentiated papillary mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors.
|
30171198 |
2019 |