NFKB1, nuclear factor kappa B subunit 1, 4790

N. diseases: 551; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE A deficit in sensory gating measured by the suppression of P50 auditory event-related potential (ERP) has been implicated in the biological bases of schizophrenia and some other psychiatric disorders and proposed as a candidate endophenotype for genetic studies. 17014995 2007
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia 		0.320 GeneticVariation disease BEFREE Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans. 29477724 2018
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia 		0.320 Biomarker disease BEFREE Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. 26279205 2015
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia 		0.320 Biomarker disease CTD_human
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		0.010 Biomarker group BEFREE The protein expression levels of RAS, RAF, nuclear factor (NF)-κB P65 and P50 as well as inhibitor of NF-κB-α of the TLR4 signaling pathway in AIDS-KS and KS tissues were higher than those in normal tissues. 30651761 2019
CUI: C1333296
Disease: Activated B-cell type diffuse large B-cell lymphoma
Activated B-cell type diffuse large B-cell lymphoma 		0.010 Biomarker disease BEFREE In conclusion, these data show that p50 is important as a unique mechanism of R-CHOP-resistance in activated B-cell-like diffuse large B-cell lymphoma and in patients without TP53 mutations. 28281555 2017
CUI: C0001306
Disease: Acute alcoholic liver disease
Acute alcoholic liver disease 		0.200 Therapeutic disease RGD Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. 27939985 2017
CUI: C0701807
Disease: Acute anterior uveitis
Acute anterior uveitis 		0.010 Biomarker disease BEFREE Moreover, inhibition of NF-kB activation remarkably suppressed both progression of AAU and total S100A8 levels in leukocytes and the iris-ciliary body after LPS administration. 27786310 2016
CUI: C0730315
Disease: Acute central serous chorioretinopathy
Acute central serous chorioretinopathy 		0.010 Biomarker disease BEFREE Between the baseline P50 amplitude and the visual acuities of the affected eyes, a strong correlation was noted at baseline (r = -0.691, p < 0.001) and a moderate correlation was noted after CSCR resolution (r = -0.422, p = 0.031). 31822040 2019
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.030 GeneticVariation disease BEFREE The aim of the present study was to explore the association between NFKB1 gene rs28362491 (-94ATTGins/del) polymorphism and ACS. 30910844 2019
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.030 Biomarker disease BEFREE Two miRNAs (hsa-miR-29 and hsa-miR-1) and three TFs (NFIC, NFKB1 and RELA) were critical genes involved in pathological process of ACS. 31550669 2019
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.030 GeneticVariation disease BEFREE The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts. 23671649 2013
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.010 Biomarker disease BEFREE <b>Aim:</b> The purpose of this study is to examine the protective effects of Dapsone on inflammation of intestinal tissue through inhibition of NF-kB pathway in acetic acid-induced colitis in rats.<b>Methods:</b> Acute colitis was produced by intra-rectal instillation of 2 mL of 4% acetic acid diluted in normal saline. 31621446 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.020 GeneticVariation disease BEFREE The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts. 23671649 2013
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.020 GeneticVariation disease BEFREE NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome. 30910844 2019
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.010 GeneticVariation disease BEFREE NF-κB1 genotype and cytomegalovirus infection were significantly associated with risk of aGVHD II-IV (p = 0.022, HR = 3.17, 95 % CI:1.18-8.51 and p = 0.048, HR = 2.56, 95 % CI:1.01-6.52, respectively). 31813598 2019
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Biomarker disease CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200 2018
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker disease CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200 2018
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.020 Biomarker disease BEFREE Interestingly, p49/p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia. 1612589 1992
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.020 Biomarker disease BEFREE To investigate the possible role of inhibiting NF-kB activation in sensitizing tumor cells to chemotherapy-induced apoptosis, we transfected the dominant-negative mutant inhibitor of NF-kB (IkBm) into the EU-1 cell line, an acute lymphoblastic leukemia (ALL) line with constitutive NF-kB activation. 14603254 2003
CUI: C4528668
Disease: Acute myeloid leukaemia refractory
Acute myeloid leukaemia refractory 		0.010 Biomarker disease BEFREE Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells. 27105509 2016
CUI: C0748355
Disease: Acute respiratory distress
Acute respiratory distress 		0.020 GeneticVariation disease BEFREE An NFKB1 promoter insertion/deletion polymorphism influences risk and outcome in acute respiratory distress syndrome among Caucasians. 21573030 2011
CUI: C0748355
Disease: Acute respiratory distress
Acute respiratory distress 		0.020 GeneticVariation disease BEFREE Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome. 17468848 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.370 AlteredExpression group LHGDN EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. 18032824 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.370 Biomarker group CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472 2009