NFKB1, nuclear factor kappa B subunit 1, 4790

N. diseases: 551; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition. 18804908 2009
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN NF-kappa B genes have a major role in inflammatory breast cancer. 18248671 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Acquisition of stable inducible up-regulation of nuclear factor-kappaB by tumor necrosis factor exposure confers increased radiation resistance without increased transformation in breast cancer cells. 18234964 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. 18316610 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. 18031796 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. 18505918 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells. 18158619 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. 17620428 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Nuclear factor-kappaB accounts for the repressor effects of high stromal cell-derived factor-1alpha levels on Tac1 expression in nontumorigenic breast cells. 17409218 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. 17638883 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Also, the amount of immunostained nuclei for RelB (P = 0.025) and NFkB1 (P = 0.031) was higher in ER- breast tumors versus ER+ breast tumors. 16740744 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group BEFREE Also, the amount of immunostained nuclei for RelB (P = 0.025) and NFkB1 (P = 0.031) was higher in ER- breast tumors versus ER+ breast tumors. 16740744 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. 15688415 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines. 15830705 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB. 15056731 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. 15044484 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway. 12471041 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN The clinical significance between activation of nuclear factor kappa B transcription factor and overexpression of HER-2/neu oncoprotein in Taiwanese patients with breast cancer. 12867284 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group BEFREE Additionally, the I kappa B homolog Bcl-3, which functions to stimulate transcription with p50 or p52, was also activated in breast tumors. 10713699 2000