Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The results of our study indicate that NGF protects neuroblastoma against injury triggered by Aβ25-35 via suppression of ROS-JNK/c-Jun pathway stimulation through the Nrf2/HO-1 pathway.
|
31605506 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, we identified the estrogen-NGF crosstalk, as well as a set of other NHRs, as potential prognostic markers and targets for therapeutic strategies against NB.
|
29374092 |
2018 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the regulation of TG2 transamidase activity by NGF in retinoic acid-induced differentiating mouse N2a and human SH-SY5Y neuroblastoma cells.
|
29242118 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pretreatment with AITC significantly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, decreased tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2), and nitric oxide (NO) production in activated microglia, and increased the nerve growth factor (NGF) and neurite outgrowth in neuroblastoma cells.
|
28671636 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics.
|
25921289 |
2015 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pheochromocytoma and neuroblastoma arise from neural crest progenitors that compete for growth factors such as nerve growth factor (NGF) during development.
|
24469107 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons.
|
25026432 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KIF1B is a candidate tumor-suppressor gene in neuroblastoma whose function is to mediate apoptosis when nerve growth factor becomes limiting in the developing nervous system.
|
24706657 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated PCD during NB regression.
|
23778138 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The LPCX retroviral vector was used to achieve stable transduction of NGF complementary DNA into BE(2)C neuroblastoma cells.
|
21683221 |
2011 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forced re-expression of endogenous TRKA and p75NTR with exposure to the HDAC inhibitor TSA sensitized neuroblastoma cells to NGF-mediated apoptosis.
|
21123453 |
2011 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We isolated and characterized an HUCB-derived population of progenitors (HUCBNP), differentiated toward neuronal phenotype by human neuroblastoma-conditioning medium (CM) and nerve growth factor (NGF), which have been found to confer neuroprotection toward hypoxia-mediated neuronal injury.
|
19458627 |
2009 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro differentiation of the HUCBNPs was achieved by treatment with 10% human SH-SY5Y neuroblastoma cell-conditioning media (CM) supplemented with 10 ng/ml nerve growth factor (NGF).
|
17873363 |
2007 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that CPPy can induce the differentiation of NB cell lines by facilitating NGF-induced TrkA/Ras/MAPK signal transduction, and may therefore be an effective therapeutic agent for NB.
|
17409494 |
2007 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present studies are designed to examine if huperzine A exerts its neuroprotective activity against oxidative stress damage through increasing the synthesis of NGF in SHSY5Y neuroblastoma cells.
|
16111675 |
2005 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TrkAIII exhibits neuroblastoma xenograft tumor-promoting activity associated with the induction of a more angiogenic and stress-resistant neuroblastoma phenotype and antagonises nerve growth factor/TrkAI antioncogenic signaling.
|
16556046 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differences in gene expression profile among SH-SY5Y neuroblastoma subclones with different neurite outgrowth responses to nerve growth factor.
|
15992370 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both low- and high-affinity NGF receptors were expressed in perinatal neuroblast hyperplasia but not in neuroblastoma tumor tissue.
|
15314226 |
2004 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this report, we detail mechanisms by which nerve growth factor (NGF) decreases N-myc levels in TrkA-transfected NB cells and its effect on NB cell proliferation.
|
14691455 |
2004 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TrkAIII antagonizes NGF/TrkAI signaling, which is responsible for NB growth arrest and differentiation through Ras/MAPK, and its expression is promoted by hypoxia at the expense of NGF-responsive receptors, providing a mechanism for converting NGF/TrkA/Ras/MAPK antioncogenic signals to TrkAIII/IP3K/Akt/NF-kappaB tumor-promoting signals during tumor progression.
|
15488758 |
2004 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that c-Jun/AP-1, through up-regulation of NCAM140, plays an important role in both NGF-induced neuronal differentiation and resistance to apoptosis induced by NO in neuroblastoma cells.
|
12101231 |
2002 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Favorable neuroblastomas usually express TrkA, the receptor for nerve growth factor (NGF), whereas unfavorable, MYCN-amplified neuroblastomas usually express TrkB and its ligand, brain-derived neurotrophic factor (BDNF).
|
12438236 |
2002 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of exogenous trkA in neuroblastoma cells restores their ability to differentiate in response to nerve growth factor (NGF).
|
11205744 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results also show that the signaling effector SH2-B is a substrate of NGF-mediated Trk signaling in NB, whereas it is not activated by NGF in rat pheochromocytoma PC12 cells.
|
10803465 |
2000 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SK-N-BE neuroblastoma cell clones transfected with p75(NTR) and lacking Trk neurotrophin receptors, previously reported to undergo extensive spontaneous apoptosis and to be protected by nerve growth factor (NGF) (Bunone, G., Mariotti, A., Compagni, A., Morandi, E., and Della Valle, G. (1997) Oncogene 14, 1463-1470), are shown to exhibit (i) increased levels of the pro-apoptotic lipid metabolite ceramide and (ii) high activity of caspases, the proteases of the cell death cascade.
|
10336437 |
1999 |