Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The same chromosome region entails at least a major risk gene for type 2 diabetes (T2D) within NIDDM2, the non-insulin-dependent-diabetes 2 locus.
|
21496327 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Type 2 diabetes has a replicated linkage on chromosome12q24.2 (NIDDM2 locus/non-insulin-dependent diabetes mellitus 2 locus), near the HNF-1alpha/MODY3 gene.
|
20069546 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes.
|
17516568 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The gene for MODY3 diabetes, HNF1alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend toward association for common missense variants in HNF1alpha with glucose-related traits.
|
16046299 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
|
14988275 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Rather, they strongly suggest that a previously undetected type 2 diabetes locus exists 50 cM from NIDDM2 on 12q.
|
10535461 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Taken together with our recent findings of linkage between this region on chromosome 12 and an insulin-deficient form of NIDDM (NIDDM2), the data suggest that mutations at the MODY3/NIDDM2 gene(s) result in a reduced insulin secretory response, that subsequently progresses to diabetes and underlines the importance of subphenotypic classification in studies of diabetes.
|
9045858 |
1997 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
We infer the existence of a gene NIDDM2 causing NIDDM associated with low insulin secretion, and suggest that NIDDM2 and MODY3 may represent different alleles of the same gene.
|
8782826 |
1996 |
Diabetes
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is implicated in diabetes in mice.
|
21496327 |
2011 |
Diabetes Mellitus
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is implicated in diabetes in mice.
|
21496327 |
2011 |
Diabetes
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Taken together with our recent findings of linkage between this region on chromosome 12 and an insulin-deficient form of NIDDM (NIDDM2), the data suggest that mutations at the MODY3/NIDDM2 gene(s) result in a reduced insulin secretory response, that subsequently progresses to diabetes and underlines the importance of subphenotypic classification in studies of diabetes.
|
9045858 |
1997 |
Diabetes Mellitus
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Taken together with our recent findings of linkage between this region on chromosome 12 and an insulin-deficient form of NIDDM (NIDDM2), the data suggest that mutations at the MODY3/NIDDM2 gene(s) result in a reduced insulin secretory response, that subsequently progresses to diabetes and underlines the importance of subphenotypic classification in studies of diabetes.
|
9045858 |
1997 |