|
Neuroblastoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
In conclusion, the high expressions of Nnat were found to be associated with good prognoses in neuroblastoma, which might indicate tumor differentiation, and its suppressions in unfavorable tumors are considered to be under epigenetic control.
|
17762496 |
2007 |
|
Neuroblastoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the high expressions of Nnat were found to be associated with good prognoses in neuroblastoma, which might indicate tumor differentiation, and its suppressions in unfavorable tumors are considered to be under epigenetic control.
|
17762496 |
2007 |
|
Neuroblastoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In 44 NB samples, the expression levels of TrkA, BIN1, and neuronatin beta were determined using quantitative reverse transcriptase-polymerase chain reaction; furthermore, the correlation between the expression of these genes' expression levels and the clinical progression of NB were assessed.
|
18082705 |
2007 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We determined the frequency of neuronatin expression in surgically resected samples from non-small cell lung carcinoma (51 adenocarcinoma and 41 squamous cell carcinoma) by immunohistochemical staining, and investigated the correlations between expression level and various clinicopathological features.
|
17805055 |
2007 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Of the more than 200 genes upregulated by these treatments, three of these, neuronatin, metallothionein 3 and cystatin E/M, were frequently hypermethylated and transcriptionally downregulated in NSCLC cell lines and tumors.
|
17043644 |
2007 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer).
|
28181547 |
2017 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
An analysis of DNA methylation in two potential regulatory regions of the NNAT locus by pyrosequencing revealed significant hypomethylation of the tumors compared to normal kidney tissue.
|
23825673 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We propose novel biomarkers and genes relevant for pathogenesis, including NNAT as a potential tumor suppressor in myxoid liposarcomas.
|
24345474 |
2013 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Further studies revealed that ACRC, CLU, MEST, and NNAT were often hypermethylated in primary ES tumors.
|
23508900 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Collectively, these findings point to an important role for NNAT in the pituitary and perhaps tumour development in this gland.
|
19218280 |
2009 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In conclusion, the high expressions of Nnat were found to be associated with good prognoses in neuroblastoma, which might indicate tumor differentiation, and its suppressions in unfavorable tumors are considered to be under epigenetic control.
|
17762496 |
2007 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Neuronatin expression is specific for tumor tissue and was detected in both pulmonary adenocarcinoma and squamous cell carcinoma at high frequency, particularly in less differentiated tumors.
|
17805055 |
2007 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
An optimum formulation for in vivo application, PEI22/Tf-PEG-PEI/PEI22-PEG5, containing plasmid DNA encoding for the tumor necrosis factor (TNF-alpha), inhibited tumor growth in three different murine tumor models.
|
12526712 |
2003 |
|
Lafora Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Aggregation of Neuronatin within cortical neurons and resulting cell death is the hallmark of Lafora disease, a progressive and fatal neurodegenerative disease.
|
24345642 |
2014 |
|
Lafora Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the neuronatin-induced aberrant Ca(2+) signaling and endoplasmic reticulum stress might underlie LD pathogenesis.
|
23408434 |
2013 |
|
Lafora Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overall, our results indicate that malin negatively regulates neuronatin and its loss of function in LD results in increased accumulation of neuronatin, which might be implicated in the formation of Lafora body or other aspect of disease pathogenesis.
|
21742036 |
2011 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
NNAT mRNA and protein also correlated with survival in human breast cancer patients.
|
31165373 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
NNAT mRNA and protein also correlated with survival in human breast cancer patients.
|
31165373 |
2019 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Neuronatin (Nnat) is an imprinted gene implicated in human obesity and widely expressed in neuroendocrine and metabolic tissues in a hormone- and nutrient-sensitive manner.
|
29864031 |
2018 |
|
Obesity
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Neuronatin expression is downregulated in obese children and has been associated with stochastic obesity in C57BL/6 mice.
|
30279096 |
2018 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
NNAT expression determined by immunohistochemistry might therefore become a helpful additional biomarker to identify high-risk breast cancer patients.
|
28540450 |
2017 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
NNAT expression determined by immunohistochemistry might therefore become a helpful additional biomarker to identify high-risk breast cancer patients.
|
28540450 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
|
24345642 |
2014 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
|
24345642 |
2014 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our findings suggest that the frequently observed overexpression of both NNAT splice forms in MB enhances growth in this cancer.
|
18701710 |
2008 |