|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with both CCAD and diffuse sinonasal polyps had an allergy prevalence approaching that of CCAD and an asthma prevalence approaching CRSwNP NOS.
|
31600866 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.
|
29729549 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified four rare nonsynonymous variants that were significantly associated with asthma following severe RSV bronchiolitis, including single variants in ADRB2, FLG and NCAM1 in European Americans (p = 4.6x10-4, 1.9x10-13 and 5.0x10-5, respectively), and NOS1 in African Americans (p = 2.3x10-11).
|
26587832 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modest evidence for association with asthma was observed for 2 CNVs near NOS1 and SERPINA3.
|
23517041 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate comprehensively the association between single nucleotide polymorphisms (SNPs) in all three NOS genes and FENO in an adult population, and to assess whether such associations are modified by asthma or atopy.
|
22368302 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SNPs (N = 121) belonging to NOS1, NOS2 and NOS3 genes were genotyped in 1277 adults from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA).
|
22590587 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Environmental factors and atopic status will enhance the asthmatic risk for children who carry NOS1 susceptible allele.
|
20609134 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this project was to evaluate the association of NOS polymorphisms and environmental exposures with FeNO levels among children with asthma.
|
19603529 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Arginases have been proposed to contribute to asthma pathogenesis by limiting the arginine substrate available to NOS enzymes, but expression of any of these enzymes has not been extensively studied in primary human cells.
|
18384429 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria.
|
18086269 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The CA-repeat and the C5266T SNP in NOS1 exon 29 have been associated with asthma and IgE levels.
|
17536218 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOS1 AAT repeat polymorphism associated with the risk of ACS (P=0.001) in patients without physician-diagnosed asthma.
|
17351927 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOS1 exon 29 CA-repeat may be a risk factor for asthma susceptibility and mite specific IgE response in a Colombian population.
|
17536218 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that inducible NOS can play a role in atopic disorders, and several polymorphisms in its gene may be important for asthma protection or susceptibility.
|
17177683 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOS1 C5266T and NOS3 G894T were not associated with asthma, atopy or FeNO.
|
16238787 |
2005 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant differences were found for allele or genotype frequencies of the 5266 C/T polymorphism in exon 29 of the NOS1 gene between IgE-mediated allergic diseases (or asthma alone) and healthy subjects.
|
15080837 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NOS1 intron 2 GT repeat and STAT6 exon 1 GT repeat were associated with asthma.
|
14767694 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether the number of AAT repeats in intron 20 of the NOS1 gene, recently associated with variations in FENO in adults with asthma and cystic fibrosis, was associated with the raised FENO in healthy atopic children.
|
12911502 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In summary, fine mapping data enable us to confine asthma candidate regions, while variants of EDN1 and NOS1, or nearby genes, may play an important role in this context.
|
11668616 |
2001 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism, also in the NOS1 gene, for high IgE levels (p=0.022).
|
11668616 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings provide support, from case-control association analysis, for NOS1 as a candidate gene for asthma.
|
10833424 |
2000 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population.
|
10673365 |
2000 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We show that addition of NOS1 genotype to the case definition of asthma allows the identification of a uniform cohort of patients, with respect to FENO, that would have been indistinguishable by other physiologic criteria.
|
11112111 |
2000 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that variants of the NOS1 gene may be one source of genetic risk for asthma.
|
10641565 |
1999 |