NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 AlteredExpression disease BEFREE Our study shows that both p-STAT3 and inducible NOS expression was upregulated in PBMCs and colonic mucosa, especially in patients with active CD. 23472658 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 AlteredExpression disease BEFREE We hypothesize that nitric oxide may modulate senescence in CD; epithelial cells of CD had higher levels of NOS2 expression than in UC (P = 0.001). 22970173 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 Biomarker disease BEFREE Polymorphisms in the NOS2A gene, which codes for the inducible nitric oxide synthase [(i)NOS], have been tested for association with several autoimmune diseases such as Crohn's disease or type 1 diabetes. 19635578 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 GeneticVariation disease BEFREE To assess the influence of inducible and endothelial nitric oxide synthase gene (NOS2A and NOS3) polymorphisms in susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). 16634870 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.150 Biomarker disease BEFREE ELOCA enabled quantitation of multiple mRNAs in small mucosal biopsies from untreated patients with CIIBD and supported a role for IL-8 and iNOS in acute inflammation in both UC and CD. 9072008 1997