NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. 19650939 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Second, an ANOVA was used to test the significance of an association between eNOS genotype and the level of blood pressure within the entire population except for 167 hypertensive subjects who had been under treatment for hypertension. 10205226 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Salt intake affects the relation between hypertension and the T-786C polymorphism in the endothelial nitric oxide synthase gene. 16364825 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN Endothelial nitric oxide synthase genetic variation and essential hypertension risk in Han Chinese: the Fangshan study. 18769442 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE With regard to the Glu298Asp polymorphism in NOS3, the odds ratio for the presence of hypertension in individuals having the Glu/Glu genotype of NOS3 when compared with those having the other genotypes (Asp/Asp and Asp/Glu) was 2.79. 19373110 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Associations of NOS3 polymorphisms with hypertension, preeclampsia, stroke, and diabetes remain uncertain. 17018701 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension. 19132956 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Although endothelial nitric oxide synthase (eNOS) haplotypes have been associated with hypertension, it is unknown whether eNOS genotypes/haplotypes are associated with resistance to antihypertensive therapy. 17082721 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension. 17594145 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE The endothelial nitric oxide synthase (eNOS) (4a/b) gene polymorphism contributes to coronary heart disease and hypertension risk. 12923396 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD. 14682408 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN [NOS3 gene polymorphism and left ventricular hypertrophy in patients with essential hypertension]. 12494183 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study. 22470539 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men. 17563560 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications. 27557897 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE NOS3 T-786C was also related to hypertension (p=0.049). 17126309 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE A single nucleotide variant of the angiotensinogene gene (AGT M235T) and endothelial nitric oxide synthase gene (eNOS G894T) have been associated with hypertension. 17977523 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Obese subjects had a 3.27-times higher risk (OR = 3.27, 95% CI: 2.37 - 4.52) of hypertension than non-obese, and in obese the NOS3 894T allele was associated with 1.37 fold higher risk of hypertension (P = 0.031). 26579574 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension. 18325347 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN While endothelial nitric oxide synthase (eNOS) haplotypes have been associated with HT, it is unknown whether eNOS genotypes/haplotypes are associated with altered susceptibility to HT in patients with T2DM. 16427644 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Markers at the peroxisome proliferative activated receptor gamma coactivator 1α (PPARGC1A) and bradykinin β2 receptor (BDKRB2) genes were nominally associated with greater risk of hypertension, although one marker each at the BDKRB2 and endothelial nitric oxide synthase-3 (NOS3) genes were nominally associated with lower risk. 20944660 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE This study did not show a strong involvement of ecNOS4 gene polymorphism, at least in the basal NO production in patients with essential hypertension, however, it indicated that ecNOS4 gene polymorphism might modulate changes in BP due to water load in patients on hemodialysis, thus indicating that these polymorphisms may be involved in the pathophysiology of volume-dependent hypertension. 10867538 2000
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN NOS3 T-786C was also related to hypertension (p=0.049). 17126309 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE ART induces endothelial dysfunction and arterial hypertension by epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene. 28323978 2017