|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Previous studies revealed that there were various mutations on endothelial nitric oxide synthase (eNOS) gene and these mutations might be a risk factor for coronary artery disease (CAD), myocardial infarction (MI), and hypertension (HT).
|
17151815 |
2006 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In addition, our results suggest two eNOS haplotypes associated with a protective effect against hypertension in both ethnic groups, and one eNOS haplotype conferring susceptibility to hypertension in white subjects.
|
16168996 |
2006 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Specifically, polymorphisms of the endothelial nitric oxide synthase gene (eNOS) have been reported to be associated with multiple health conditions including DR, hypertension, nephropathy, and cardiovascular diseases in several ethnic groups.
|
18079690 |
2007 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension.
|
18698212 |
2008 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In patients with T2DM, homozygosity for the eNOS Asp298 allele was a significant risk factor (HR 3.12 [1.49-6.56], p = 0.003), but not in subjects without diabetes or hypertension.
|
19077211 |
2008 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT.
|
17306574 |
2007 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
|
27618448 |
2016 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We investigated the association of the eNOS E298D polymorphism with hypertension and with blood pressure (BP) in a large population-based sample of Caucasian ethnicity.
|
15942458 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension.
|
11710784 |
2001 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
LHGDN |
The 894T and -786C alleles of the NOS3 gene were significantly associated with both hypertension and CVD in renal allograft recipients.
|
18331440 |
2008 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
While endothelial nitric oxide synthase (eNOS) haplotypes have been associated with HT, it is unknown whether eNOS genotypes/haplotypes are associated with altered susceptibility to HT in patients with T2DM.
|
16427644 |
2006 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Variations in the eNOS gene have been correlated with a number of human diseases including hypertension, coronary vasospasm, smoking dependent risk of coronary disease, myocardial infarction and placental disruption.
|
15825252 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Studies in ART mice demonstrating premature vascular aging and arterial hypertension further demonstrate the potential of ART to increase cardiovascular risk and have allowed to unravel epigenetic alterations of the eNOS gene as an underpinning mechanism.
|
24964004 |
2014 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The present study evidenced that rs1799983 NOS3 polymorphism could be associated with hypertension and DBP among Southern Europeans, being this association influenced by dietary fat (SFA and MUFA) and body mass index.
|
26994605 |
2017 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2.
|
15662218 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase haplotypes associated with hypertension do not predispose to cardiac hypertrophy.
|
20070154 |
2010 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
It was found that the frequencies of b/b, b/a and a/a genotypes of the eNOS4 gene were 84.06%, 15.22% and 0.72% in the control group, and 81.46%, 15.89% and 2.65% in the hypertension group, respectively.
|
17492127 |
2007 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase polymorphisms and hypertension.
|
12530931 |
2003 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.
|
24623205 |
2014 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The stepwise multiple regression analysis in these patients showed that hypertension (F = 9.760) and ecNOS gene polymorphism (F = 5.298) are the relevant variables for nephropathy.
|
10868974 |
2000 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with coronary artery disease and hypertension in various populations.
|
19574729 |
2009 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects.
|
11905585 |
2002 |