NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 GeneticVariation phenotype BEFREE This study aimed to explore the roles of endothelial nitric oxide synthase (eNOS) in the control of metastasis of infection with endothelial dysfunction, as well as the roles of -786T>C polymorphism in eNOS promoter in the control of metastasis of endothelial function. 31209933 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 AlteredExpression phenotype BEFREE Furthermore, a correlation was observed between the expressions of eNOS and invasive tumor, metastasis and poor survival in urothelial carcinoma in The Cancer Genome Atlas data set. 30611644 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 Biomarker phenotype BEFREE A pairwise analysis of the staining data for eNOS and its upstream regulators showed that a concurrent increase in eNOS/VEGFR3, eNOS/ephrin-A1, eNOS/VEGFC and eNOS/EphA3 was significantly associated with metastasis. 27143607 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 GeneticVariation phenotype BEFREE It was found that, compared with NOS3 -690C>T variant CC genotype, CT and TT genotypes confer decreased risk of developing metastases (dominant model, P = 0.015, OR, 0.24; 95% CI, 0.07-0.88) and show association with low clinical tumour stage, compared with stages T3 and T4 (dominant model, P = 0.046, OR, 0.20; 95% CI, 0.04-1.02). 23998439 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 GeneticVariation phenotype BEFREE When comparing women with invasive versus pre-invasive breast cancer, the eNOS-786 TT and eNOS 894 GG genotypes were associated with a greater likelihood of invasive disease and the eNOS 894 GG genotype was associated with a greater likelihood of having metastatic disease. 17891484 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 GeneticVariation phenotype BEFREE To evaluate the impact of the NOS3 polymorphisms on vascular invasion and metastasis in breast cancer patients. 14623178 2003