A literature search was performed for case-control studies from inception to July 30, 2018 focusing on eNOS polymorphism (-786T>C) and risk of migraine.
Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).
The aim of this study was to investigate three endothelial nitric oxide synthase (eNOS) polymorphisms in 176 patients with migraine and 123 healthy individuals.
Several genetic risk factors have been associated with migraine, but no study has unraveled a possible relationship between migraine and eNOSGlu298Asp.
In this study, we detected a polymorphism for endothelial nitric oxide synthase by polymerase chain reaction and tested this for association and linkage to migraine.