NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Disease: Malignant lymphoma, stem cell type ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0431132
Disease: Malignant lymphoma, stem cell type
Malignant lymphoma, stem cell type 		0.010 Biomarker disease BEFREE Lymphoma cells grown in this model exhibited excellent biomimetic properties compared to conventional 2D culture including (1) enhanced chemotherapy resistance, (2) suppressed rate of apoptosis, (3) upregulated expression of drug resistance genes (MDR1, MRP1, BCRP and HIF-1α), (4) elevated levels of tumor aggressiveness factors including Notch (Notch-1, -2, -3, and -4) and its downstream molecules (Hes-1 and Hey-1), VEGF and MMPs (MMP-2 and MMP-9), and (5) enrichment of a lymphoma stem cell population. 29416753 2018