NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY. 28582442 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Both NPY and CGRP were higher in PD patients with comorbid depression compared to MDD patients. 28659833 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Biomarker disease BEFREE Overall, increased delivery of NPY to the CNS for AD might be an effective therapy especially if combined with an anti-Aβ therapeutic. 26620558 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Biomarker disease BEFREE Numbers of neuropeptide Y (NPY) and parvalbumin (PV) immunoreactive (IR) cells were decreased in the hippocampus of 1 month-old TgCRND8 mouse AD model in a sub-regionally specific manner. 28154533 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Biomarker disease BEFREE Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons. 25026432 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Using a recombinant adeno-associated viral (rAAV) vector, we addressed this idea by testing effects on anxiolytic- and depression-like behaviours in adult mice after overexpression of NPY transgene in the amygdala and/or hippocampus, two brain regions implicated in emotional behaviours. 25267070 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Using a recombinant adeno-associated viral (rAAV) vector, we addressed this idea by testing effects on anxiolytic- and depression-like behaviours in adult mice after overexpression of NPY transgene in the amygdala and/or hippocampus, two brain regions implicated in emotional behaviours. 25267070 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Association of the NPY gene with alcohol dependence was tested by using logistic regression and haplotype analyses and linkage disequilibrium. 23652361 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Association of the NPY gene with alcohol dependence was tested by using logistic regression and haplotype analyses and linkage disequilibrium. 23652361 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 AlteredExpression disease BEFREE However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE NPY has recently gained much attention as an endogenous antiepileptic and antidepressant agent, as drugs with antiepileptic and/or mood-stabilizing properties may exert their action by increasing NPY concentrations, which in turn can reduce anxiety and depression levels, dampen seizures or increase seizure threshold. 23994577 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE NPY has recently gained much attention as an endogenous antiepileptic and antidepressant agent, as drugs with antiepileptic and/or mood-stabilizing properties may exert their action by increasing NPY concentrations, which in turn can reduce anxiety and depression levels, dampen seizures or increase seizure threshold. 23994577 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. 22938859 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease BEFREE Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. 22938859 2012
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Therapeutic disease RGD We suggest that NPY, perhaps acting via NPY Y1 receptors, might interact with the endogenous cholinergic system and play a role in improving the learning and memory processes in the rats with AD-like condition. 22266216 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found, but higher affinity of IgG autoAbs for NPY was associated with lower body mass index and prevented NPY-induced orexigenic response in mice after their central injection. 22365482 2012