NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Disease: Metabolic Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 Biomarker group BEFREE In this review, we summarize the structural characteristics of human NPY receptors and their role in metabolic diseases. 29310113 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 GeneticVariation group BEFREE A gain-of-function polymorphism in human neuropeptide Y (<i>NPY</i>) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D). 28468933 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 Biomarker group BEFREE Taken together, these results suggest that insulin actions in NPY neurons is critical for maintaining energy balance and an impairment of this pathway may be causally linked to the development of metabolic diseases. 28580287 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 Biomarker group BEFREE When overexpressed, NPY in noradrenergic neurons increases adiposity in gene-dose-dependent fashion, and leads to metabolic disorders such as impaired glucose tolerance. 26681068 2016
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 GeneticVariation group BEFREE There are many association studies between the NPY gene variants and cardiovascular and metabolic disease. 18499283 2008