|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor cells and MDSCs secrete IL6, which activates STAT3 within cancer cells.
|
30670491 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combining targeted delivery and dual responsive release of DOX significantly improves the therapeutic efficacy of AP-ZIF-90@DOX in MDA-MB-231 tumor bearing mouse, and results in 80% survival rate over 40 days of treatment.
|
30640136 |
2019 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
The analysis of NPY methylation is promising, as it has the additional advantage that no prior knowledge of tumor mutations is needed.
|
29605591 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study aimed to investigate if combined analysis of pro-Neuropeptide Y (NPY) and ERG expression in tumor tissue are associated with biochemical failure (BF), castration-based treatment, castration-resistant prostate cancer (CRPC), and prostate cancer (PCa)-specific death for men undergoing radical prostatectomy (RP) for PCa.
|
30191621 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data establish the existence of a microRNA-mediated cross talk between enteric neurons producing NPY and intestinal epithelial cells, and the potential of neuropeptide-regulated miRNAs as potential therapeutic molecules for the management of inflammation-associated tumors in the gut.
|
27856419 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
|
27251038 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of NPY and its receptors was evaluated in corresponding samples of tumor RNA, tissues, and sera from 87 patients with neuroblastic tumors and in tumor tissues from the TH-MYCN NB mouse model.
|
27743558 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, NPY and Y5R were upregulated in a BDNF-independent manner in NB cells under pro-apoptotic conditions, such as serum deprivation and chemotherapy, as well as in cell lines and tissues derived from posttreatment NB tumors.
|
25132261 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Significantly higher NPY concentrations were detected in patients with ES who had tumors of pelvic and bone origin.
|
25387699 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The neuropeptide Y (NPY) Y(1) receptor (Y(1)R) has been suggested as a tumor marker for in vivo imaging and as a therapeutic target.
|
23236424 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In human neuroblastoma tissues, the expression of Y2R was observed in both tumor and endothelial cells, while NPY was predominantly expressed in neuroblastoma cells.
|
20676138 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Selective NPY analogues are potent tools for tumour targeting.
|
19890892 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study examined influences of hereditary factors and differences in catecholamine production on tumour expression of NPY, as assessed by quantitative PCR, enzyme immunoassay and immunohistochemistry.
|
17470513 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NPY receptors on renal tumor cells and tumor blood vessels may therefore be the molecular targets of endogenous NPY released by intratumoral nerve fibers.
|
15704095 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, neuropeptide Y-induced feeding appears to be inhibited in this tumor anorexia model, and this may correlate with increased expression of corticotropin-releasing hormone.
|
15567470 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No relation was found between NPY mRNA expression in tumor tissue and NPY plasma concentrations of the ten patients (r = 0.08; p = 0.81).
|
9802408 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found NPY mRNA expression in 30 of 38 tumors; 15 of 15 Stage IVS tumors from children under 1 year of age at diagnosis expressed NPY mRNA, whereas 0 of 4 Stage IV tumors from children less than 1 year of age at diagnosis expressed NPY mRNA.
|
2393870 |
1990 |