|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression.
|
30504424 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
All these results suggest that NPY and Y2R in the mPFC are involved in the pathophysiology of depression and NPY plays an antidepressant role in the mPFC mainly via Y2R, which suppresses the NLRP3 signaling pathway, in LPS-induced depression model rats.
|
31736656 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder.
|
31082535 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025).
|
30213237 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition to this decrease in depression-like behavior, brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release increased in the hippocampus in response to MAI treatment, but estradiol levels did not recover.
|
29643431 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY.
|
28582442 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review, we present an overview of findings with regard to the NPY system in relation to anxiety and stress, acute as well as chronic; furthermore we discuss post-traumatic stress disorder and, in part depression.
|
28824541 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both NPY and CGRP were higher in PD patients with comorbid depression compared to MDD patients.
|
28659833 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression.
|
23468908 |
2013 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
NPY has recently gained much attention as an endogenous antiepileptic and antidepressant agent, as drugs with antiepileptic and/or mood-stabilizing properties may exert their action by increasing NPY concentrations, which in turn can reduce anxiety and depression levels, dampen seizures or increase seizure threshold.
|
23994577 |
2013 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript.
|
23697793 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found, but higher affinity of IgG autoAbs for NPY was associated with lower body mass index and prevented NPY-induced orexigenic response in mice after their central injection.
|
22365482 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression.
|
19854625 |
2010 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, novel evidence from polymorphisms in the prepro-NPY gene has shed new light on the potential clinical relevance of NPY in depression.
|
19782662 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Pro7 allele of preproNPY protected against depression among Swedes.
|
19264362 |
2009 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The data support our hypothesis that the NPY system dysregulation constitutes one of the biological underpinnings of depression and that one common mechanism of action of antidepressive treatment modalities may be effects on NPY and its receptors.
|
17572454 |
2007 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression.
|
16611091 |
2006 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Neuropeptide Y (NPY) was shown to modulate anxiety- and depression-related behaviors in various animal models.
|
16691011 |
2006 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Neurochemical and/or pharmacological evidence suggests that the FSL rat exhibits changes consistent with the cholinergic, serotonergic, dopaminergic, NPY, and circadian rhythm models but not the noradrenergic, HPA axis or GABAergic models of depression.
|
15925699 |
2005 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Human studies of central NPY levels in depression have, however, been inconclusive.
|
14757324 |
2004 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings point to the potential of the NPY system for developing novel pharmacological treatments of stress-related disorders, including anxiety and depression.
|
12013027 |
2002 |