NPPB, natriuretic peptide B, 4879

N. diseases: 193; N. variants: 4
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.010 AlteredExpression phenotype BEFREE In ISO-CHF rats, oral administration of Nat (1, 3, 9 mg·kg<sup>-1</sup>·d<sup>-1</sup>) or Ipt (3 mg·kg<sup>-1</sup>·d<sup>-1</sup>) for 60 days significantly improved cardiac dysfunction, reversed cardiac remodeling, significantly attenuated the pathological increases in BNP levels, and improved endothelial dysfunction by adjusting the balance between endothelin and NO systems. 27890915 2017