|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings suggest that a combination of subunit displacement and reduced Nrf1 expression may be responsible for c-20S impairment in EAE.
|
31709534 |
2020 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The following clusters were found in the dendrogram: Nrf2 and p21 with ATP5B and GADPH in all the tissues and with NRF1 in all except the tumor tissues with metastasis; Bach1 with ATP5B and GAPDH in the tumor tissues; Keap1 with p62 in all the tissues, with LC3 in the tumor tissues and with NRF1 and HO1 in the tumor tissues with metastasis.
|
31796664 |
2020 |
|
Optic Atrophy 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the hormone induced the expression of the nuclear respiratory factors 1 and 2 (Nrf-1 and Nrf-2), the mitochondrial transcription factors A (Tfam) and B2 (TFB2M), and the optic atrophy 1 (OPA1).
|
31676390 |
2020 |
|
Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that complex I deficiency leads to a redox potential alteration and a significant reduction of sirtuin 1 (SIRT1) expression, a major deacetylase sensitive to the cellular redox state, and NRF1 the downstream target of SIRT1.
|
31655048 |
2020 |
|
Melanocytic nevus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, NRF1 mRNA levels decreased from benign naevi to dysplastic naevi (<i>p</i> = 0.034).
|
31687076 |
2019 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the results of the present study have uncovered a novel mechanism in which CXCR4 expression is regulated by Nrf‑1 in WERI‑Rb1 cells, thereby identifying novel potential targets for the treatment of RB, and providing evidence for the clinical application of TMP in adjuvant retinoblastoma therapy.
|
31322174 |
2019 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the virus infection at the late stage (at 16 h after infection) stimulated TFAM expression but decreased the levels of both NRF1 and NRF2, indicating that virus infection activated TFAM signaling independent of either NRF1 or NRF2.
|
31011285 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, overexpression of NRF‑1 increased the expression of B‑cell lymphoma‑2, hypoxia inducible factor‑1α and NRF‑2.
|
30628711 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrf1 and Nrf2 are relevant in disease presentation and overall survival in high-risk DLBCL.
|
30755497 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
|
30833558 |
2019 |
|
Pelvic Organ Prolapse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference in the TFAM(p = 0.377), NRF-1 and NRF-2 expression between the POP and non-POP groups (p = 0.647; p = 0.682).
|
31307745 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have identified an unexpected collaboration between MyoD and NRF1 under androgen-depleted condition, which may serve as an important adaptive mechanism during the pathogenesis of castration-resistant prostate cancer.
|
29730257 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mitochondria in AMs from IPF patients had prominent morphological defects and impaired transcription paralleled to a significant reduction of mitochondria homeostasis regulators PINK1, PARK2 and NRF1. mtROS, was significantly higher in IPF and associated with reduced expression of mitochondria-encoded oxidative phosphorylation (OXPHOS) genes.
|
31775876 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
NRF-1 regulates stress response genes that contain the antioxidant response element (ARE), and HCMV infection is associated with increased expression of many stress response genes when US27 is present.
|
30209167 |
2018 |
|
Glaucoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the conditional Nrf1 allele we have generated provides the opportunity to develop novel mouse models to understand how defective mitochondrial biogenesis contributes to the pathologies and disease progression of several neurodegenerative diseases, including glaucoma, age-related macular degeneration, Parkinson's diseases, and Huntington's disease.
|
30333037 |
2018 |
|
Corneal Neovascularization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our data suggest TMP downregulates CXCR4 by repressing NRF-1 expression in CNV, likely indirectly by downregulating NFκB.
|
29801148 |
2018 |
|
Malignant neoplasm of brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This was consistent with our observation of higher NRF1 protein expression in the experimental model of HER2+ breast cancer brain metastasis.
|
30128822 |
2018 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autophagy attenuates compression-induced apoptosis of human nucleus pulposus cells via MEK/ERK/NRF1/Atg7 signaling pathways during intervertebral disc degeneration.
|
29908161 |
2018 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This was consistent with our observation of higher NRF1 protein expression in the experimental model of HER2+ breast cancer brain metastasis.
|
30128822 |
2018 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings identified a negative feedback loop between miR-378 and Nrf1 that promotes the pathogenesis of hepatosteatosis, and suggests the use of miR-378 as a potential therapeutic target for NAFLD.
|
29625129 |
2018 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
This highly novel role of NRF1 in the stochastic acquisition of BCSC-like subsets and their progression to a malignant phenotype may open an entirely new research direction targeting NRF1 signaling in invasive breast cancer.
|
30486409 |
2018 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
However, mechanistic aspects by which NRF1 may contribute to susceptibility to different breast tumor subtypes are still not fully understood.
|
30128822 |
2018 |
|
HER2-positive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical confirmation of our machine learned Bayesian networks will have significant impact on our understanding of the role of NRF1 as a valuable biomarker for breast cancer diagnosis and prognosis as well as provide strong rationale for future studies to develop NRF1 signaling-based therapeutics to target HER2+ breast cancer.
|
30128822 |
2018 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |