Bowen's Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers.
|
21514422 |
2011 |
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury.
|
18723421 |
2008 |
Right Ventricular Hypertrophy
|
0.200 |
Biomarker
|
disease |
RGD |
Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function.
|
17704287 |
2007 |
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
Biomarker
|
disease |
BEFREE |
Such dual control of the two pathways by NRF-1 place it as critical gene in the design of therapeutic modalities much needed to cure or better manage type 2 diabetes.
|
28263745 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men.
|
23210442 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (rs1882095) increased the risk of type 2 diabetes.
|
21146886 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The present study shows an association of SNPs in the NRF1 gene with type 2 diabetes in a Han Chinese population.
|
18071027 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes associations in PPARG, KCNJ11, and SLC2A2; identified significant SNPs in genes with previously reported associations (ENPP1 [rs2021966, P = 0.00026] and NRF1 [rs1882095, P = 0.00096]); and implicated novel genes, including RAPGEF1 (rs4740283, P = 0.00013) and TP53 (rs1042522, Arg72Pro, P = 0.00086), in type 2 diabetes susceptibility.
|
18678618 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The NRF1 gene was sequenced to identify polymorphisms in 24 Korean DNA samples and then common variants were genotyped in 766 patients with type 2 diabetes and 303 non-diabetic subjects.
|
16082529 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function.
|
12832613 |
2003 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results suggest that Nrf1 and TFAM are potential biomarkers for the determination of individualized therapy and the prognosis of breast cancer, and molecular targeting of Nrf1 and TFAM is a promising strategy for the sensitization of breast cancer cells to chemotherapeutics.
|
29434836 |
2018 |
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
With the Luminal A subtype of breast cancer, higher NRF1 expression is associated with lower survival.
|
29995872 |
2018 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Since transcriptional control of NRF1 seems to be dependent on epidermal growth factor receptor signaling, herein, we investigated the role of NRF1 in estrogen receptor/progesterone receptor negative, but human epidermal growth factor receptor 2-positive (ER/PR -ve HER2 +ve) breast cancer.
|
30128822 |
2018 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
The gain of NRF1 and/or treatment with 17β-estradiol (E2) produced heterogeneous breast cancer stem cell (BCSC)-like subsets composed of more than 10 distinct cell sub-populations.
|
30486409 |
2018 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The gain of NRF1 and/or treatment with 17β-estradiol (E2) produced heterogeneous breast cancer stem cell (BCSC)-like subsets composed of more than 10 distinct cell sub-populations.
|
30486409 |
2018 |
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
With the Luminal A subtype of breast cancer, higher NRF1 expression is associated with lower survival.
|
29995872 |
2018 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results suggest that Nrf1 and TFAM are potential biomarkers for the determination of individualized therapy and the prognosis of breast cancer, and molecular targeting of Nrf1 and TFAM is a promising strategy for the sensitization of breast cancer cells to chemotherapeutics.
|
29434836 |
2018 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Since transcriptional control of NRF1 seems to be dependent on epidermal growth factor receptor signaling, herein, we investigated the role of NRF1 in estrogen receptor/progesterone receptor negative, but human epidermal growth factor receptor 2-positive (ER/PR -ve HER2 +ve) breast cancer.
|
30128822 |
2018 |
Malignant neoplasm of breast
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
|
26492917 |
2015 |
Breast Carcinoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
|
26492917 |
2015 |
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer.
|
18823535 |
2008 |
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our analysis found that motifs bound by ELK1, E2F, NRF1 and NFY are potential regulatory motifs that positively correlate with malignant progression of breast cancer.
|
18823535 |
2008 |