|
Abnormal behavior
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
There is a highly homologous NURR1 gene in humans (formerly known as NOT) which therefore constitutes a good candidate gene for neurologic and psychiatric disorders with an involvement of the dopamine neuron system, such as Parkinson's disease, schizophrenia, and manic-depression.
|
11121187 |
2000 |
|
Abnormal behavior
|
0.310 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
[Transudative bile peritonitis in the elderly].
|
516625 |
1979 |
|
Acute cerebral ischemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results of further <i>in vivo</i> study revealed that anti-miR-145-5p administration brought about increasing expression of Nurr1 and reduction of infarct volume in acute cerebral ischemia.
|
29209166 |
2017 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In human DA neurons, which provide an appropriate cellular milieu, VPA treatment alters the expression of several genes important for dopaminergic neuron function including DAT, Nurr1, and TH; this might partly explain its action in regulating addictive behaviors.
|
27547496 |
2016 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In summary, miR-331-5p is a key regulatory factor of Nurr1, and rhynchophylline can participate in the process of resistance to ketamine addiction through the miR-331-5p/Nurr1/BDNF pathway or inhibition of CREB phosphorylation.
|
29476799 |
2018 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Knock-down experiments with siRNA targeting NR4A2 increase migration of gastrin treated adenocarcinoma AGS-GR cells, while ectopically expressed NR4A2 increases apoptosis and hampers gastrin induced invasion, indicating a tumor suppressor function of NR4A2.
|
24086717 |
2013 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, NR4A2 expression is elevated in Apc-/+ mouse adenomas and its levels were further increased following PGE2 treatment.
|
16293616 |
2006 |
|
Adenosquamous carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We detected MAML2 rearrangement using fluorescence in situ hybridization (FISH) in tissue samples from 42 cases of PMEC and 40 of adenosquamous carcinoma (ASC), and the expression of potential downstream targets of MECT1-MAML2, including HES1, FLT1 and NR4A2 with immunohistochemistry (IHC).
|
24714697 |
2014 |
|
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In adrenocortical neoplasms (n = 44), Nurr1 immunoreactivity was higher in aldosteronoma than in Cushing's adenoma or adrenocortical carcinoma.
|
15292355 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
LHGDN |
However, they revealed a significant association between the NR4A2 gene haplotype and alcohol dependence, indicating that 2q22-q23 including the NR4A2 gene locus is a possible genomic region contributing to genetic susceptibility to alcohol dependence.
|
11840500 |
2002 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans.
|
23066323 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans.
|
23066323 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
However, they revealed a significant association between the NR4A2 gene haplotype and alcohol dependence, indicating that 2q22-q23 including the NR4A2 gene locus is a possible genomic region contributing to genetic susceptibility to alcohol dependence.
|
11840500 |
2002 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Similarly, the OD of Nurr1 immunofluorescence intensity in the nigra of AD cases was decreased in neurons with neurofibrillary tangles (NFTs).
|
16320253 |
2006 |
|
Alzheimer's Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of NR4A2 is connected to AD progression, and activation of its may improve cognitive function.
|
30684217 |
2019 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
These in vivo and in vitro findings suggest that Nurr1 critically regulates AD-related pathophysiology and identify Nurr1 as a novel AD therapeutic target.
|
30515963 |
2019 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the role of topo IIβ association with Nuclear receptor related 1 protein (Nurr1) in the onset of AD.
|
28124588 |
2017 |
|
Angelman Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also show that the protein level of melanocortin 1 receptor (Mc1r) and nuclear receptor subfamily 4, group A, member 2 (Nr4a2) in the AS mice cerebellum is decreased relative to that of the wild-type mice.
|
20571502 |
2010 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggest that Nurr1 has an important role in the progression of PDAC and may be used as a novel marker for therapeutic targets.
|
28352330 |
2017 |
|
Anthrax disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we bacterially expressed and isolated a human Nurr1 fusion protein containing a N-terminal cell delivery domain derived from detoxified anthrax lethal factor followed by wild type ubiquitin with deubiquitinating enzyme recognition site for intracellular cleavage.
|
30121937 |
2019 |
|
Arsenic Encephalopathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Induced Polyneuropathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Poisoning, Inorganic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |