|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings should stimulate future studies to probe the ligandability and druggability of Nurr1 for both endogenous and synthetic ligands, which could lead to new therapeutics for Nurr1-related diseases, including Parkinson's disease and schizophrenia.
|
30416039 |
2019 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that the identified polymorphic sites in the human NURR1 are unlikely to be involved in conferring susceptibility for SZ or PD in our patient material.
|
12815740 |
2003 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia.
|
31455763 |
2019 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G).
|
15211629 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals.
|
12627459 |
2003 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia.
|
15635645 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results failed to reveal significant link between NR4A2 polymorphism and SZ risk.
|
25982322 |
2015 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia.
|
11803525 |
2001 |
|
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We detected decreased expression of RARG and NR4A2 mRNAs in females with schizophrenia (p<0.05).
|
27992436 |
2016 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In parallel, NURR1 has been also linked to dopamine-associated brain disorders, such as Parkinson's disease (PD) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mDA).
|
31574937 |
2019 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our aim was to evaluate the influence of NR4A2 gene in the performance of schizophrenia (SZ) patients and healthy subjects on a sustained attention task.
|
22294735 |
2013 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NURR1 mutations in cases of schizophrenia and manic-depressive disorder.
|
11121187 |
2000 |
|
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder.
|
16631355 |
2006 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further analysis of the polymorphism of the human Nurr1 gene may reveal the association with diseases characterized by changes of the DA system, such as Parkinson's disease and schizophrenia.
|
10216261 |
1999 |
|
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
P<i>ostmortem</i> DLPFC expression data analysis showed decreased expression levels of NURR1 and ERR1 in patients with SCZ.
|
31811028 |
2020 |
|
Bipolar Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
NURR1 mutations in cases of schizophrenia and manic-depressive disorder.
|
11121187 |
2000 |
|
Bipolar Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Bipolar Disorder
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder.
|
16631355 |
2006 |
|
Bipolar Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G).
|
15211629 |
2004 |
|
Colorectal Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
NR4A2 expression in epithelials consecutively increased from adenoma, adjacent mucosa to CRC (P(trend)<0.001).
|
23809767 |
2013 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.
|
19549529 |
2009 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer.
|
21757690 |
2011 |
|
Colorectal Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Human colorectal cancers relative to matched normal mucosa showed increased NR4A2 expression.
|
16293616 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans.
|
23066323 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |