|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
|
30852740 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Second, hyperglycemia is accompanied by increased circulating MG53 in humans and rodents with diabetes mellitus.
|
30586741 |
2019 |
|
Heart valve disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Conclusions Together, our data characterize valve interstitial cell membrane repair as a novel mechanism of protection against valvular remodeling and assess potential in vivo roles of MG 53 in preventing valvular heart disease.
|
30741589 |
2019 |
|
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
First, high glucose or high insulin induces MG53 secretion from isolated rodent hearts and skeletal muscle.
|
30586741 |
2019 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Lack of immunohistochemical expression of TRIM72 in the tumor was significantly and independently associated to recurrence.A recent report by Chen et al. has shown that TRIM72 can be measured in plasma for colon carcinoma detection as an alternative to CEA or CA19.9, with lower levels in patients with carcinoma.
|
30852740 |
2019 |
|
Retroviridae Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The stable MG53 overexpression/knockdown SCC9 and SCC25 cells are constructed through retrovirus infection.
|
30690890 |
2019 |
|
Ventricular arrhythmia
|
0.010 |
Biomarker
|
disease |
BEFREE |
MG53 knockout enhances I<sub>to,f</sub> remodeling and action potential duration prolongation and increases susceptibility to ventricular arrhythmia in mouse cardiac hypertrophy.
|
30760025 |
2019 |
|
Malignant neoplasm of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, the role of MG53 in the tumorigenesis of tongue cancer is analyzed in vitro and in vivo.
|
30690890 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, MG53 ameliorated LPS-induced memory impairment and neuronal cell death in mice.
|
31260721 |
2019 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, MG53 ameliorated LPS-induced memory impairment and neuronal cell death in mice.
|
31260721 |
2019 |
|
Tongue Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The findings demonstrate that MG53 affects the biological behavior of human tongue cancer SCC9 and SCC25 cells.
|
30690890 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, the role of MG53 in the tumorigenesis of tongue cancer is analyzed in vitro and in vivo.
|
30690890 |
2019 |
|
Aortic valve disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methods and Results We found that MG 53 is expressed in pig and human patient aortic valves and observed aortic valve disease in aged Mg53-/- mice.
|
30741589 |
2019 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch-1 signaling.
|
30820965 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Whether MG53 can help remove abnormal mitochondria and relieve CKD-induced muscle atrophy requires further study.
|
30614598 |
2019 |
|
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MG53 increased with the extent of atrial fibrosis, which could induce AF.
|
29233682 |
2018 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
|
Sore to touch
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Among the unusual proteins, Four and a half LIM domains 1 (FHL1) and Tripartite motif protein 72 (TRIM72) correlated respectively negatively and positively with beef tenderness.
|
29412918 |
2018 |
|
Cytokine storm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic ablation of TRIM72 led to improved pathogen clearance, reduced cytokine storm, and improved survival in murine models of severe pneumonia, specificity of which was confirmed by adoptive transfer of wild-type or TRIM72<sup>KO</sup> AMs to AM-depleted TRIM72<sup>KO</sup> mice.
|
29268030 |
2018 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
|
Muscular Dystrophies, Limb-Girdle
|
0.010 |
Biomarker
|
group |
BEFREE |
Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B.
|
28750735 |
2017 |
|
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we tested whether rhMG53 protein can improve membrane repair in a dysferlin-deficient mouse model of LGMD2B (B6.129-Dysf<sup>tm1Kcam</sup>/J).
|
28750735 |
2017 |
|
Muscular Dystrophy, Duchenne
|
0.010 |
Biomarker
|
disease |
BEFREE |
MG53 has been implicated in cardiac ischaemia-reperfusion injury, and serum MG53 provides a biomarker of skeletal muscle injury in the mdx mouse model of Duchenne muscular dystrophy.
|
26790476 |
2016 |
|
Lung diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data indicate a physiological function for MG53 in the lung and suggest that targeting membrane repair may be an effective means for treatment or prevention of lung diseases.
|
25034454 |
2014 |