Muscular Dystrophy, Duchenne
|
0.010 |
Biomarker
|
disease |
BEFREE |
MG53 has been implicated in cardiac ischaemia-reperfusion injury, and serum MG53 provides a biomarker of skeletal muscle injury in the mdx mouse model of Duchenne muscular dystrophy.
|
26790476 |
2016 |
Metabolic Syndrome X
|
0.020 |
Biomarker
|
disease |
BEFREE |
TRIM72 is involved in insulin resistance and metabolic syndrome, which are risk factors of colon cancer.
|
29806630 |
2018 |
Ventricular arrhythmia
|
0.010 |
Biomarker
|
disease |
BEFREE |
MG53 knockout enhances I<sub>to,f</sub> remodeling and action potential duration prolongation and increases susceptibility to ventricular arrhythmia in mouse cardiac hypertrophy.
|
30760025 |
2019 |
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch-1 signaling.
|
30820965 |
2019 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
|
30852740 |
2019 |
Sore to touch
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Among the unusual proteins, Four and a half LIM domains 1 (FHL1) and Tripartite motif protein 72 (TRIM72) correlated respectively negatively and positively with beef tenderness.
|
29412918 |
2018 |
Heart valve disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Conclusions Together, our data characterize valve interstitial cell membrane repair as a novel mechanism of protection against valvular remodeling and assess potential in vivo roles of MG 53 in preventing valvular heart disease.
|
30741589 |
2019 |
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters.
|
22314291 |
2012 |
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MG53 increased with the extent of atrial fibrosis, which could induce AF.
|
29233682 |
2018 |
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
First, high glucose or high insulin induces MG53 secretion from isolated rodent hearts and skeletal muscle.
|
30586741 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, the potential involvement of circulating MG53 in the pathogenesis of T2DM was assessed by neutralizing blood MG53 with monoclonal antibodies in diabetic db/db mice.
|
30586741 |
2019 |
Cytokine storm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic ablation of TRIM72 led to improved pathogen clearance, reduced cytokine storm, and improved survival in murine models of severe pneumonia, specificity of which was confirmed by adoptive transfer of wild-type or TRIM72<sup>KO</sup> AMs to AM-depleted TRIM72<sup>KO</sup> mice.
|
29268030 |
2018 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, the role of MG53 in the tumorigenesis of tongue cancer is analyzed in vitro and in vivo.
|
30690890 |
2019 |
Malignant neoplasm of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, the role of MG53 in the tumorigenesis of tongue cancer is analyzed in vitro and in vivo.
|
30690890 |
2019 |
Muscular Dystrophy
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that systemic delivery and muscle-specific overexpression of human MG53 gene by recombinant adeno-associated virus (AAV) vectors enhanced membrane repair, ameliorated pathology, and improved muscle and heart functions in δ-sarcoglycan (δ-SG)-deficient TO-2 hamsters, an animal model of MD and congestive heart failure.
|
22314291 |
2012 |
Congestive heart failure
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that systemic delivery and muscle-specific overexpression of human MG53 gene by recombinant adeno-associated virus (AAV) vectors enhanced membrane repair, ameliorated pathology, and improved muscle and heart functions in δ-sarcoglycan (δ-SG)-deficient TO-2 hamsters, an animal model of MD and congestive heart failure.
|
22314291 |
2012 |
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we tested whether rhMG53 protein can improve membrane repair in a dysferlin-deficient mouse model of LGMD2B (B6.129-Dysf<sup>tm1Kcam</sup>/J).
|
28750735 |
2017 |
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Herein, we will review the link between structural and molecular remodelling of the sarcolemma associated with the progression of HF, specifically considering the evidence for: (i) Whether intrinsic, evolutionary conserved, plasma membrane injury-repair mechanisms are in operation in the heart, and (ii) if deficits in key 'wound-healing' proteins (annexins, dysferlin, EHD2 and MG53) may play a yet to be fully appreciated role in triggering sarcolemma microdomain remodelling and/or necrosis.
|
31520263 |
2019 |
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Herein, we will review the link between structural and molecular remodelling of the sarcolemma associated with the progression of HF, specifically considering the evidence for: (i) Whether intrinsic, evolutionary conserved, plasma membrane injury-repair mechanisms are in operation in the heart, and (ii) if deficits in key 'wound-healing' proteins (annexins, dysferlin, EHD2 and MG53) may play a yet to be fully appreciated role in triggering sarcolemma microdomain remodelling and/or necrosis.
|
31520263 |
2019 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the lower serum TRIM72 levels were associated with advanced clinical stage, lymph node, and distant metastases in colon cancer patients.
|
29806630 |
2018 |
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, MG53 ameliorated LPS-induced memory impairment and neuronal cell death in mice.
|
31260721 |
2019 |
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, MG53 ameliorated LPS-induced memory impairment and neuronal cell death in mice.
|
31260721 |
2019 |